Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages

JAD Reports
Swati RaneAlzheimer’s Disease Neuroimaging Initiative

Abstract

This work explores the feasibility of combining anatomical MRI data across two public repositories namely, the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Progressive Parkinson's Markers Initiative (PPMI). We compared cortical thickness and subcortical volumes in cognitively normal older adults between datasets with distinct imaging parameters to assess if they would provide equivalent information. Three distinct datasets were identified. Major differences in data were scanner manufacturer and the use of magnetization inversion to enhance tissue contrast. Equivalent datasets, i.e., those providing similar volumetric measurements in cognitively normal controls, were identified in ADNI and PPMI. These were datasets obtained on the Siemens scanner with TI = 900 ms. Our secondary goal was to assess the agreement between subcortical volumes that are obtained with different software packages. Three subcortical measurement applications (FSL, FreeSurfer, and a recent multi-atlas approach) were compared. Our results show significant agreement in the measurements of caudate, putamen, pallidum, and hippocampus across the packages and poor agreement between measurements of accumbens and amygdala. This is likely due to their ...Continue Reading

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Citations

Dec 5, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Swati RaneDaniel O Claassen
Sep 6, 2019·Neurology·Anand J C EijlersJeroen J G Geurts
Jun 6, 2021·Brain Structure & Function·Jaime Gómez-Ramírez, Javier J González-Rosa

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Software Mentioned

FIRST
Multi
FreeSurfer
Atlas
FSL
Accumbens

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