Comparison of cortical EEG responses to realistic sham versus real TMS of human motor cortex

Brain Stimulation
Pedro Caldana GordonUlf Ziemann

Abstract

The analysis of cortical responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) has been successfully applied to study human cortical physiology. However, in addition to the (desired) activation of cortical neurons and fibers, TMS also causes (undesired) indirect brain responses through auditory and somatosensory stimulation, which may contribute significantly to the overall EEG signal and mask the effects of intervention on direct cortical responses. To test differences in EEG responses to real TMS at intensities above and below resting motor threshold (RMT) and a realistic sham stimulation. 12 healthy subjects participated in one session in which single-pulse TMS was applied to the left motor cortex in 3 different blocks, 150 pulses per block: 110%RMT, 90%RMT and realistic sham stimulation. Cortical responses were collected by a 64 electrode EEG system. TMS evoked potentials (TEPs) and TMS induced oscillations were analyzed. 12 healthy subjects participated in one session in which single-pulse TMS was applied to the left motor cortex in 3 different blocks, 150 pulses per block: 110%RMT, 90%RMT and realistic sham stimulation. Cortical responses were collected by a 64-channel EEG system. T...Continue Reading

Citations

Jul 11, 2019·Brain Topography·Karita S-T SaloRisto J Ilmoniemi
Mar 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Recep A OzdemirEmiliano Santarnecchi
May 12, 2019·Brain Topography·Agnese ZazioDomenica Veniero
Nov 1, 2020·Brain Stimulation·Lorenzo RocchiJohn Rothwell
Mar 21, 2021·Nature Communications·Domenica VenieroGregor Thut
Apr 1, 2021·Journal of Neurophysiology·Lara FernandezPeter G Enticott
Apr 16, 2021·Scientific Reports·Paolo BelardinelliUlf Ziemann
May 25, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jeanette HuiZafiris J Daskalakis
Jun 19, 2021·NeuroImage·Giacomo BertazzoliMarta Bortoletto
Jun 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mohsen PoorganjiZafiris J Daskalakis
Aug 29, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Agnese ZazioMarta Bortoletto
Jan 26, 2022·Journal of Neural Transmission·Dominik PizemIrena Rektorova
Jan 28, 2022·Scientific Reports·Jessica M RossMouhsin M Shafi

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