Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue

Artificial Cells, Nanomedicine, and Biotechnology
Chia-Hui ChuangYing-Chieh Chen

Abstract

Timely tissue vascularization and integration of engineered tissues into a patient plays an important role in the successful translation of engineered tissues into clinically relevant therapies. To decrease the time needed to vascularize an engineered adipose tissue, suitable local microenvironments provided by hydrogels to support cell-based functional vascular network formation have been investigated. Using the same biomolecule in solution, two types of hydrogels can be obtained: a "physical hydrogel" which is thermal-induced self-assemble fibril initiation and growth, due to amino and carboxyl telopeptides on collagen chains, and a "chemical hydrogel" which results from the covalently cross-linking of the side chains induced by one step enzyme mediation in aqueous solution. In this paper, we compare the capability of engineering vascular network and large-sized vascularized adipose tissue in vivo in different types of collagen hydrogels, physical and chemical crosslinking. The relationships between vascular network formation and hydrogel properties for the two types of hydrogels are discussed. Finally, we successfully engineered a vascularized adipose tissue construct (∼877.6 adipocytes/mm2; 94% area of a construct) in the a...Continue Reading

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Citations

Jun 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·John A TerrellChengpeng Chen
May 12, 2020·Frontiers in Bioengineering and Biotechnology·Gabriele NaselloJosé Manuel García-Aznar
Apr 11, 2020·Tissue Engineering. Part B, Reviews·Jianrui Ma, Chengyang Huang
Oct 9, 2020·Scientific Reports·Gabriella Maria Fernandes-CunhaDavid Myung
Mar 2, 2021·Advanced Science·Barbara Blanco-FernandezJoão F Mano
May 22, 2021·Trends in Biotechnology·Gretel S MajorKhoon S Lim
Aug 7, 2021·Micromachines·Kena SongJinghua Li

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