Comparison of current diagnostic criteria for acute-on-chronic liver failure

PloS One
Qian ZhangYing Liu

Abstract

Currently, acute-on-chronic liver failure (ACLF) has been defined differently by Asia-Pacific Association for the Study of the Liver (APASL) and Chinese Medical Association (CMA) in the East, as well as EASL-Chronic Liver Failure (EASL-CLIF) Consortium in the West. This study aimed to compare current different diagnostic criteria for ACLF and to determine predictors of the progression into post-enrollment EASL-CLIF ACLF from ACLF at enrollment defined by APASL alone or by both APASL and CMA but not by EASL-CLIF Consortium. We retrospectively analyzed clinical data from 394 eligible cirrhotic patients fulfilling at least APASL criteria for ACLF at enrollment. Patient survival was estimated by Kaplan-Meier analysis and subsequently compared by log-rank test. Independent predictors of disease progression were determined using univariate analysis and multivariate Cox regression analysis. The 90-day mortality rate was 13.1% in patients with ACLF at enrollment defined by APASL alone, 25.3% in patients with ACLF at enrollment defined by both APASL and CMA but not EASL-CLIF Consortium, and 59.3% in patients with ACLF at enrollment defined by EASL-CLIF Consortium in addition to APASL. Baseline Chronic Liver Failure-Sequential Organ Fail...Continue Reading

References

Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MalinchocP C ter Borg
Feb 1, 2005·World Journal of Gastroenterology : WJG·Jian-He GanJie Xu
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andres E RufFederico G Villamil
May 16, 2006·Gastroenterology·Scott W BigginsGoran Klintmalm
Aug 2, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pere Ginès, Mónica Guevara
Sep 5, 2008·The New England Journal of Medicine·W Ray KimTerry M Therneau
Jul 15, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C-Y HsuS-D Lee
Feb 18, 2011·Current Opinion in Critical Care·Jody C Olson, Patrick S Kamath
Aug 31, 2011·World Journal of Gastroenterology : WJG·Kun HuangXiao-Yan Liu
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jody C OlsonPatrick S Kamath
Oct 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hitendra GargShiv Kumar Sarin
Mar 21, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Kama A WlodzimirowRobert A F M Chamuleau
Jul 4, 2012·Journal of Hepatology·Rajiv JalanPatrick S Kamath
Nov 29, 2012·Critical Care : the Official Journal of the Critical Care Forum·Rajiv JalanRajeshwar P Mookerjee
Mar 12, 2013·Gastroenterology·Richard MoreauUNKNOWN CANONIC Study Investigators of the EASL–CLIF Consortium
Apr 30, 2013·Gastroenterology·Jasmohan S Bajaj
Jan 18, 2014·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Elham Ahmed Hassan, Abeer Sharaf El-Din Abd El-Rehim
Jan 25, 2014·Clinical and Molecular Hepatology·Tae Yeob Kim, Dong Joon Kim
Jul 24, 2015·Hepatology International·Shiv Kumar SarinUNKNOWN APASL ACLF Working Party

❮ Previous
Next ❯

Citations

Feb 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Shiv K Sarin, Ashok Choudhury
Aug 8, 2015·Journal of Gastroenterology and Hepatology·Qiongling BaoLanjuan Li
Nov 1, 2015·Colloids and Surfaces. B, Biointerfaces·Era JainAshok Kumar
Mar 16, 2016·Frontiers of Medicine·Jing ZhangKe-Qin Hu
Aug 4, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Qian ZhangHua Liu
Jan 24, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoshi MochidaHajime Takikawa
Jun 10, 2016·Nature Reviews. Disease Primers·Vicente ArroyoBernd Schnabl
Nov 2, 2016·Expert Review of Gastroenterology & Hepatology·Ankur JindalShiv Kumar Sarin
Nov 18, 2015·World Journal of Gastroenterology : WJG·Sara Blasco-AlgoraConrado M Fernández-Rodríguez
Nov 12, 2015·World Journal of Hepatology·Harneet Singh, C Ganesh Pai
Apr 5, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Feinv Chen, Lianqing Lou
Apr 28, 2021·European Journal of Gastroenterology & Hepatology·Ahmed El RayMahmoud Sherbiny
Jun 15, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Bershic ValantineAyaskanta Singh

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.