PMID: 15354974Sep 10, 2004Paper

Comparison of cystatin C, creatinine and creatinine clearance vs. GFR for detection of renal failure in renal transplant patients

Renal Failure
Jean-Philippe DanielThierry Hannedouche

Abstract

Serum cystatin C (Scyst) has been suggested as an alternative index of glomerular filtration rate (GFR) and could be useful in renal transplant patients. In a 60-subject cohort (40 +/- 12 years old), we compared the simultaneous measurements of Scyst, serum creatinine (Screat), creatinine clearance (Ccreat), Cockcroft and Gault's estimated clearance (Ccg) and GFR measured using inulin clearance (Cin). Receiver operating characteristic (ROC) analysis was performed using two Cin cut-off (60 and 90 mL/min/1.73 m2). A significant correlation was found among Cin on one hand and 1/Scyst, Ccreat, 1/Screat and Ccg on the other hand. Best fits (sensitivity/specificity) at 90 mL/min/1.73 m2 were 1.18 mg/L (0.72/0.80) for Scyst, 1.32 mg/dL (0.67/0.90) for Screat, 77 mL/min (0.80/0.70) for Ccg and 104 mL/min (0.88/0.80) for Ccreat. The areas under the ROC curves were not significantly different. This study provides cut-off values for Screat and Ccg for detection of renal failure in renal transplant patients. However, the results also suggest that Scyst is not a more sensitive marker than Screat or Ccg for detecting renal failure in renal transplant patients.

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Oct 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Larsen
Aug 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·O TenstadK Aukland
Dec 29, 1998·Current Opinion in Nephrology and Hypertension·F GaspariG Remuzzi
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L RischA Huber
Jan 3, 2001·Transplantation Proceedings·E ThervetD Erlich
Aug 4, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·E PaskalevA Nashkov

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Citations

Nov 1, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Sophie Séronie-VivienUNKNOWN SFBC "Biology of renal function and renal failure" working group
Mar 16, 2007·American Journal of Nephrology·Ahmed ZahranAhmed Shoker
Aug 10, 2006·Intensive Care Medicine·Christoph EllenbergerMarc Licker
Feb 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Stella S DaskalopoulouGeorge Geroulakos
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Ivana Cláudia GabrielGianna Mastroianni Kirsztajn
Dec 15, 2015·Seminars in Cardiothoracic and Vascular Anesthesia·Gary LauC David Mazer
Sep 28, 2012·Critical Care : the Official Journal of the Critical Care Forum·Marlies OstermannLui G Forni
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lorenz Risch, Andreas R Huber

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