PMID: 8081658Jul 1, 1994Paper

Comparison of cytochrome P-450 content and conjugative enzymes in livers of camels (Camelus dromedarius), guinea-pigs (Cavia porcellus) and rats (Rattus norvegicus)

Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology
Zoheir A Damanhouri, O S Tayeb

Abstract

The activities of the conjugative enzymes, glutathione S-transferase and UDP-glucuronyl-transferase, have been measured in vitro in the livers of camels, guinea-pigs and rats. Some sex differences were observed in the levels of these conjugative enzymes. In rats and guinea-pigs, females had higher UDP-glucuronyltransferase activity than males. In camels, females had higher glutathione S-transferase activity than males. In these species, the cytochrome P-450 isozymes observed between the 50,000 and 60,000 mol. wt regions have been separated and characterized by SDS-polyacrylamide gel electrophoresis. Camels showed lower levels of all types of cytochrome P-450 isozymes, while guinea-pigs showed higher levels of most of these isozymes. In general, camels seemed to have the lowest drug-metabolizing enzyme activity when compared to rats and guinea-pigs.

References

Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C R ShortJ Weissinger
Feb 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C J HoleskiG M Bellamy
Jul 1, 1985·Journal of Biochemistry·T IgarashiH Kitagawa
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D E RyanW Levin
Jul 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·Z A Damanhouri, O S Tayeb

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Citations

Sep 12, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Zoheir A Damanhouri
Feb 3, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Haider RazaAnnie John

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