Comparison of cytokine plasma levels in human African trypanosomiasis

Tropical Medicine & International Health : TM & IH
David CourtinAndré Garcia

Abstract

Immunological studies suggest that human African trypanosomiasis (HAT) is associated with inflammatory responses. A better understanding of the complex cytokine interactions regulating HAT infections is essential to elucidate the mechanisms of generalized immunosuppression. We determined levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma protein levels in plasma samples from three groups of individuals from the Democratic Republic of Congo: (i) HAT cases; (ii) seropositive individuals for whom parasite detection was negative and (ii) controls. Plasma levels of six cytokines were significantly higher in HAT cases than in both controls (P<0.003) and seropositive individuals (P<0.016). IL-2 and IL-10 concentrations were significantly lower (P<0.02) in the seropositive group than in the control one. Human African trypanosomiasis leads to the development of strong cytokine responses, indicating the potential involvement of IL-2 and IL-10 in the phenomenon of seropositivity without parasitological confirmation. This strongly suggests the involvement of immunity in this particular aspect of HAT epidemiology.

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Citations

Nov 17, 2007·The Journal of Infectious Diseases·Lorna MacleanJeremy M Sternberg
Feb 14, 2008·American Journal of Physiology. Endocrinology and Metabolism·Klemen StrleKeith W Kelley
Jun 15, 2011·PLoS Neglected Tropical Diseases·Matyáš SímaMarie Lipoldová
Jan 26, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Charles D KatoVincent P Alibu
Oct 27, 2012·Neurologic Clinics·Charlene E GamaldoJustin C McArthur
Oct 6, 2010·Seminars in Diagnostic Pathology·Geeta Chacko
May 25, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia
Jul 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laure GineauAndré Garcia
Nov 7, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Julius NsubugaVincent Pius Alibu
Jun 20, 2015·PLoS Neglected Tropical Diseases·Charles D KatoEnock Matovu
Dec 18, 2018·Frontiers in Microbiology·Sanjay VarikutiAbhay R Satoskar

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African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.