PMID: 11925383Apr 2, 2002Paper

Comparison of day 3 FSH serum values as determined by six different immunoassays

Human Reproduction
Joëlle TaiebAlbert Lindenbaum

Abstract

The accurate assessment of FSH concentration is important for evaluating ovarian function prior to IVF. However, a number of different assay techniques are currently in use, leading to inconsistencies in the hormone data being reported. To address this problem, we measured FSH concentration using a number of commercially available systems. Day 3 serum FSH levels were measured in 215 healthy fertile women using six different immunoassays: Coatria (125)I (Bio-Mérieux), ACS-180 (Bayer Diagnostics), Advia-Centaur (Bayer Diagnostics), Vitros ECi (Ortho-Clinical Diagnostics), Architect i2000 (Abbott) and Elecsys 2010 (Roche Diagnostics). According to the immunoassay, means +/- SD of FSH concentrations were: 6.5 +/- 2.2 mIU/ml for Coatria (125)I, 6.8 +/- 2.7 mIU/ml for Advia-Centaur, 6.7 +/- 3.0 mIU/ml for Vitros ECi, 7.6 +/- 3.0 mIU/ml for ACS-180, 8.2 +/- 3.3 mIU/ml for Architect i2000 and 8.8 +/- 3.0 mIU/ml for Elecsys 2010. Day 3 FSH values determined by six different immunoassays were significantly different (P < 0.01, paired t-test). Physicians must take care when interpreting results from different clinical laboratories.

Citations

Dec 1, 2010·Reproductive Biology and Endocrinology : RB&E·Jessica ScriverLisa M Pastore
Jun 19, 2014·Journal of Assisted Reproduction and Genetics·Lisa M PastoreSteven L Young
Oct 22, 2003·Reproductive Biomedicine Online·G LoverroM Tartagni
Jun 21, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Walter HublThomas Demant
May 15, 2012·Reproductive Sciences·Lisa M PastoreLawrence M Silverman

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