Comparison of del Nido and histidine-tryptophan-ketoglutarate cardioplegia solutions in pediatric patients undergoing open heart surgery: A prospective randomized clinical trial

The Journal of Thoracic and Cardiovascular Surgery
Sachin TalwarBalram Airan

Abstract

We conducted a prospective randomized controlled trial to compare del Nido (DN) and histidine-tryptophan-ketoglutarate (HTK) cardioplegia solution in pediatric patients undergoing intracardiac tetralogy of Fallot repair. One hundred consecutive patients 12 years of age or younger, undergoing intracardiac repair of tetralogy of Fallot were randomized into DN (n = 50) and HTK (n = 50) groups. Cardioplegia strategy consisted of a single dose of DN (20 mL/kg) or HTK (6 mL/kg/min for 6 minutes). Primary outcome was cardiac index (CI). Secondary outcomes were ventricular arrhythmias post cross-clamp release, time to peripheral rewarming, duration of mechanical ventilation, inotropic score, intensive care unit and hospital stay, and serum levels of troponin-I, interleukin-6, and tumor necrosis factor-α. Ultrastructural changes in the myocardium were assessed. CI was significantly higher in the DN group compared with the HTK group at 6 (P = .005) and 24 hours (P < .001) after surgery. It was on an average 0.44 L/min/m2 higher in the DN group at any time point (P = .004). Time for complete cessation of electrical activity was longer in the HTK group (P = .01) and more patients in the HTK group had ventricular arrhythmias post cross-clam...Continue Reading

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Dec 17, 2017·The Journal of Thoracic and Cardiovascular Surgery·Sachin TalwarBalram Airan

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Citations

Jan 26, 2021·The Journal of Thoracic and Cardiovascular Surgery·Chee-Hoon LeeJoon Bum Kim
Jan 27, 2021·The Journal of Thoracic and Cardiovascular Surgery·Daniel H Buitrago, Tomas A Salerno
Feb 4, 2021·Asian Cardiovascular & Thoracic Annals·Serdar GunaydinKanat Ozisik
Mar 1, 2019·The Journal of Thoracic and Cardiovascular Surgery·Koh Takeuchi
Sep 24, 2021·Asian Cardiovascular & Thoracic Annals·Pitipong Sithiamnuai, Teerapong Tocharoenchok

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