Comparison of Descemet Stripping Automated Endothelial Keratoplasty and Descemet Membrane Endothelial Keratoplasty in the Treatment of Failed Penetrating Keratoplasty

Cornea
Adi Einan-LifshitzDavid S Rootman

Abstract

To compare the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) with Descemet membrane endothelial keratoplasty (DMEK) for the treatment of failed penetrating keratoplasty (PKP). This is a retrospective chart review of patients with failed PKP who underwent DMEK or DSAEK. The median follow-up time for both groups was 28 months (range 6-116 months). Data collection included demographic characteristics, number of previous corneal transplants, previous glaucoma surgeries, best-corrected visual acuity, endothelial cell density, graft detachment and rebubble rate, rejection episodes, and graft failure. Twenty-eight eyes in the DMEK group and 24 eyes in the DSAEK group were included in the analysis. Forty-three percent of eyes in the DMEK group and 50% of eyes in the DSAEK group had to be regrafted because of failure (P = 0.80). The most common reason for failure was persistent graft detachment (58%) in the DMEK group and secondary failure (58%) in the DSAEK group; hence, the time between endothelial keratoplasty and graft failure differed significantly between the groups (P = 0.02). Six eyes (21%) in the DMEK group and 7 eyes (29%) in the DSAEK group developed graft rejection (P = 0.39). Rejection was the ca...Continue Reading

References

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Citations

Apr 13, 2020·Ophthalmology and Therapy·George D KymionisKonstantinos Droutsas
Jan 6, 2021·The British Journal of Ophthalmology·Rashmi DeshmukhRasik B Vajpayee
Sep 26, 2020·Progress in Retinal and Eye Research·Marianne O PriceFrancis W Price
May 15, 2021·Current Opinion in Ophthalmology·Jia Yin
Jun 23, 2021·American Journal of Ophthalmology·Robert W WeisenthalDavid D Verdier
Aug 12, 2021·Klinische Monatsblätter für Augenheilkunde·Philip KeyeThomas Reinhard

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