PMID: 9637380Jun 24, 1998Paper

Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane

The Veterinary Record
R C BennettS P Luna

Abstract

This prospective clinical study compared the physiological effects of two commonly used anaesthetic induction techniques in horses maintained with halothane. One hundred horses admitted for elective surgery were randomly allocated to receive either guaiphenesin (to effect) and thiopentone (5 mg/kg), or detomidine (20 microg/kg) and ketamine (2 mg/kg) for the induction of anaesthesia after acepromazine premedication. Anaesthesia was maintained with halothane in oxygen. There were no significant differences in breed, age, sex, weight, type of surgery and duration of anaesthesia between the groups. Immediately after induction of anaesthesia heart rate was higher after guaiphenesin and thiopentone, and arterial blood pressure was higher after detomidine and ketamine. Thereafter hypotension, often necessitating an infusion of dobutamine, developed in both groups. Arterial blood gases and respiratory rates were similar in the two groups. There were no significant differences between the groups in the subjectively scored quality of induction and recovery, or in recovery time.

References

Sep 1, 1986·Equine Veterinary Journal·K W Clarke, P M Taylor
Aug 1, 1968·British Journal of Anaesthesia·L W HallW S Tyler
Sep 1, 1980·Microvascular Research·J F AmendB Fichtenbaum
Mar 1, 1993·Equine Veterinary Journal·S S Young, P M Taylor
Jun 24, 1998·The Veterinary Record·W R HudsonM H Hinton

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Citations

Aug 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·S P LunaM J Wheeler
Apr 6, 2004·The Veterinary Clinics of North America. Equine Practice·Janyce Cornick-Seahorn
Oct 12, 2007·Veterinary Anaesthesia and Analgesia·Mohammad Reza Seddighi, Mehrdad Mohri
Jun 24, 1998·The Veterinary Record·H D Rodger, R H Richards
Oct 22, 2002·Journal of the American Veterinary Medical Association·Kazuto YamashitaTadao Kotani
Jun 6, 2009·Pain Practice : the Official Journal of World Institute of Pain·Buket Cagla Ozbakis AkkurtFeray Tumkaya
Oct 20, 2000·The Journal of Veterinary Medical Science·M OhtaY Mizuno
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Miguel Gozalo-Marcilla, Simone Katja Ringer

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