Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery

Anesthesiology Research and Practice
Maziar MahjoubifardAlireza Jahangirifard

Abstract

This clinical trial was conducted on 90 patients, aged 30-70 years, who had heart surgery. The participants were categorized into three groups. Group D received 1 µg/kg intravenous dexmedetomidine in 10 minutes, group L received 1.5 mg/kg lidocaine (1%) 90 seconds before intubation, and group F received 2 µg/kg fentanyl. The vital signs (HR, SBP, DBP, and MAP) were measured before intubation and 1st, 3rd, 5th, and 10th minutes after intubation. Data were analyzed with SPSS 19 software (chi-square, one-way ANOVA, or Kruskal-Wallis). The age (P=0.389) and gender distributions of patients were similar in all three groups. Dexmedetomidine significantly attenuated HR in the 3rd (P=0.001), 5th (P=0.001), and 10th (P=0.003) minutes after intervention. It also reduced the systolic blood pressure in the 5th (P=0.024) and 10th (P=0.006) minutes. This reduction was significantly higher in the dexmedetomidine group than that in the two other groups. In addition, dexmedetomidine caused a greater reduction in MAP in the 1st (P=0.048), 5th (P=0.0001), and 10th (P=0.0001) minutes. Discussion. All three medications were effective in controlling HR; however, dexmedetomidine caused bradycardia in the 3rd, 5th, and 10th minutes. Lidocaine resulted...Continue Reading

References

Aug 22, 2014·International Journal of Applied & Basic Medical Research·Siddareddigari Velayudha ReddyShaik Nawaz Ahmed
Jan 1, 2013·Anesthesia, Essays and Researches·Arpita LahaSusanta Sarkar
Oct 27, 2015·Journal of Clinical and Diagnostic Research : JCDR·Sellamuthu GunalanPaneerselvam Sunder
Oct 30, 2015·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Kamlesh KumariHarpreet Singh Sandhu
Jul 12, 2018·European Journal of Translational Myology·Mehrdad Mesbah KiaeiMasoud Ghorbanlo

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Citations

Jan 12, 2021·Journal of Lasers in Medical Sciences·Behnam Hosseini, Farzad Allameh

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Methods Mentioned

BETA
Coronary Artery Bypass

Software Mentioned

SPSS

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