Comparison of diabetic nephropathy between male and female eNOS-/-db /db mice

American Journal of Physiology. Renal Physiology
Yuhong MaRong Ma

Abstract

Sex is an important biological variable that impacts diverse physiological and pathological processes, including the progression of diabetic nephropathy. Diabetic nephropathy is one of the most common complications of diabetes mellitus and is the leading cause of end-stage renal disease. The endothelial nitric oxide synthase-deficient (eNOS-/-) db/db mouse is an appropriate and valuable model to study mechanisms in the development of diabetic nephropathy because of the similarities of the features of diabetic kidney disease in this model to those in humans. The aim of the present study was to determine whether there was a sex difference in renal injury in eNOS-/-db/db mice. Both male and female eNOS-/-db/db mice showed hyperglycemia, obesity, and renal hypertrophy. However, there was no significant difference in those variables between male and female mice. Furthermore, both male and female diabetic mice showed progressive albuminuria and significantly greater levels of serum creatinine and blood urea nitrogen compared with the same sex of wild-type mice (nondiabetic controls). Although all three variables in female eNOS-/-db/db mice had a tendency to be greater than those in male eNOS-/-db/db mice, those sex differences were n...Continue Reading

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Citations

Jan 28, 2020·American Journal of Physiology. Renal Physiology·Parisa Yazdizadeh ShotorbaniRong Ma
Dec 27, 2019·Physiological Reports·Frederikke E SembachMette V Østergaard
Apr 20, 2021·Physiological Genomics·Denisha R SpiresAlexander Staruschenko
Jun 30, 2021·BMJ Open Diabetes Research & Care·Yingzheng ZhaoGuangcui Xu
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weiwei ZhengAiyun Wang

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Methods Mentioned

BETA
genotyping
PCR
Assay
Electrophoresis

Software Mentioned

ImageJ
R
AlphaEase FC
DP manager
SigmaStat

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