Comparison of different analysis algorithms to calculate multiple-breath washout outcomes

ERJ Open Research
Pinelopi AnagnostopoulouPhilipp Latzin

Abstract

Lung clearance index (LCI) is the main outcome of the multiple-breath washout (MBW) test. Current recommendations for LCI acquisition are based on low-grade evidence. The aim of this study was to challenge those recommendations using alternative methods for LCI analysis. Nitrogen MBW measurements from school-aged children, 20 healthy controls, 20 with cystic fibrosis (CF) and 17 with primary ciliary dyskinesia (PCD), were analysed using 1) current algorithms (standard), 2) three alternative algorithms to detect with higher precision the end of MBW testing and 3) two alternative algorithms to determine exhaled tracer gas concentrations. LCI values, intra-test repeatability, and ability to discriminate between health and lung disease were compared between these methods. The analysis methods strongly influenced LCI (mean±sd overall differences (%) between standard and alternative analysis methods: -4.9±5.7%; range: -66-19%), but did not improve intra-test variability. Discrimination between health and disease was comparable as areas under the receiver operator curves were not greater than that from standard analysis. This study supports current recommendations for LCI calculation in children. Alternative methods influence LCI esti...Continue Reading

References

Oct 17, 2002·Respiratory Physiology & Neurobiology·S C M Luijendijk, C P M van der Grinten
Jan 15, 2003·The Journal of School Health·UNKNOWN Office on Smoking and Health, Division of Adolescent and School Health National Center for Chronic Disease Prevention and He
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Paul AuroraUNKNOWN London Cystic Fibrosis Collaboration
Feb 28, 2009·Respiratory Medicine·Alex Horsley
Dec 14, 2011·Journal of Applied Physiology·Sylvia VerbanckAlain Van Muylem
Nov 13, 2012·The European Respiratory Journal·Sooky LumSamatha Sonnappa
Feb 12, 2013·The European Respiratory Journal·Paul D RobinsonPer M Gustafsson
Feb 7, 2015·The European Respiratory Journal·Elizabeth R SalamonGraham L Hall
May 15, 2015·Thorax·Sylvia NyilasCordula Koerner-Rettberg
Jun 16, 2015·Annals of the American Thoracic Society·Padmaja SubbaraoWayne Morgan
Jul 15, 2015·Journal of Applied Physiology·Sophie YamminePhilipp Latzin
Aug 19, 2015·Pediatric Pulmonology·Pinelopi AnagnostopoulouPhilipp Latzin
Sep 12, 2015·American Journal of Respiratory and Critical Care Medicine·Kathryn A RamseyUNKNOWN AREST CF
Feb 6, 2016·Physiological Measurement·Pinelopi AnagnostopoulouPhilipp Latzin
Mar 24, 2016·Pediatric Research·Jonathan GrønbækHans Bisgaard
Apr 28, 2016·Inflammatory Bowel Diseases·Sophie YammineChristiane Sokollik
May 28, 2016·Journal of Applied Physiology·Sylvia NyilasPhilipp Latzin
Jun 16, 2016·PloS One·Renee JensenFelix Ratjen
Dec 7, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·William PoncinPatrick Lebecque
Dec 13, 2016·American Journal of Respiratory and Critical Care Medicine·Sanja StanojevicFelix A Ratjen
Jan 27, 2017·The European Respiratory Journal·Sylvia NyilasCordula Koerner-Rettberg
Oct 7, 2017·The European Respiratory Journal·Esther Oude EngberinkSanja Stanojevic

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Citations

May 16, 2021·Pediatric Pulmonology·Marc-Alexander OestreichKathryn A Ramsey
Jun 15, 2021·Pediatric Pulmonology·Václav Koucký

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Software Mentioned

GraphPad
Matlab
Spiroware
GraphPad Prism
Stata
LungSim

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