Comparison of different anticoagulant associations on haemostasis and biochemical analyses in feline blood specimens

Journal of Feline Medicine and Surgery
Fanny GranatNathalie Bourgès-Abella

Abstract

Objectives Universal anticoagulant could be an alternative to the multiple blood sampling required for clinical pathology investigations in cats. An association of citrate, theophylline, adenosine and dipyridamole (CTAD) has been reported to be a good substitute for EDTA for haematology analysis in cats, limiting platelet clumping, and has also been shown to be valid for haematology, secondary haemostasis and some biochemical variables in humans. The aim of the study was therefore to investigate the effects of CTAD on in vitro platelet aggregation and compare results of secondary haemostasis and biochemistry tests, excluding a priori those variables not reliably measured in CTAD, such as sodium, chloride and divalent cations, in feline blood specimens collected in CTAD and paired citrate and heparin tubes. Methods Thirty blood specimens sampled in citrate and CTAD were analysed for in vitro platelet aggregation, and 60 blood specimens sampled in citrate or heparin and CTAD were analysed for plasma coagulation and a biochemistry panel. Results In vitro platelet aggregation was inhibited in CTAD compared with citrate specimens. Prothrombin time, activated partial thromboplastin time, antithrombin and fibrinogen results were simil...Continue Reading

References

May 25, 2002·Veterinary Clinical Pathology·Elizabeth J. NormanRoger BB. Clampitt
Apr 15, 2004·The Veterinary Journal·José J CerónFernando Tecles
Oct 18, 2008·Journal of Automated Methods & Management in Chemistry·M YokotaT Takubo
Sep 10, 2009·Veterinary Clinical Pathology·Anne GeffréJean-Pierre Braun
Jan 20, 2012·Journal of the American Veterinary Medical Association·Brice S ReynoldsCatherine Trumel
Dec 18, 2012·Veterinary Clinical Pathology·Kristen R FriedrichsUNKNOWN American Society for Veterinary Clinical Pathology
Dec 11, 2013·Veterinary Clinical Pathology·Kendal E HarrUNKNOWN ASVCP

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Citations

Jun 5, 2018·Veterinary Clinical Pathology·Saverio PaltrinieriJari Zambarbieri
May 7, 2020·JMIR Public Health and Surveillance·Moshe RogosnitzkyAlejandro R Jadad

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flow cytometry

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