Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study

BMC Nephrology
F. ArnoldYakup Tanriver

Abstract

Critically ill coronavirus disease 2019 (COVID-19) patients have a high risk of acute kidney injury (AKI) that requires renal replacement therapy (RRT). A state of hypercoagulability reduces circuit life spans. To maintain circuit patency and therapeutic efficiency, an optimized anticoagulation strategy is needed. This study investigates whether alternative anticoagulation strategies for RRT during COVID-19 are superior to administration of unfractionated heparin (UFH). Retrospective cohort study on 71 critically ill COVID-19 patients (≥18 years), admitted to intensive care units at a tertiary health care facility in the southwestern part of Germany between February 26 and May 21, 2020. We collected data on the disease course, AKI, RRT, and thromboembolic events. Four different anticoagulatory regimens were administered. Anticoagulation during continuous veno-venous hemodialysis (CVVHD) was performed with UFH or citrate. Anticoagulation during sustained low-efficiency daily dialysis (SLEDD) was performed with UFH, argatroban, or low molecular weight heparin (LMWH). Primary outcome is the effect of the anticoagulation regimen on mean treatment times of RRT. In patients receiving CVVHD, mean treatment time in the UFH group was 21...Continue Reading

References

Jun 17, 1998·American Heart Journal·A G Turpie
May 23, 2002·Perfusion·Marco RanucciSimonetta Brozzi
Jul 22, 2004·Contributions to Nephrology·Andrew Davenport
Jul 20, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michael Joannidis, Heleen M Oudemans-van Straaten
Sep 28, 2015·Critical Care Clinics·Michael E O'Connor, John R Prowle
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Mar 8, 2020·Annals of Intensive Care·Ayman Karkar, Claudio Ronco
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
Apr 28, 2020·Blood·Jean M Connors, Jerrold H Levy
Apr 28, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Michele ScialpiFernando Longo
May 6, 2020·Journal of the American Society of Nephrology : JASN·Daniel BatlleUNKNOWN COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group
May 8, 2020·Nature Reviews. Immunology·Miriam Merad, Jerome C Martin
May 14, 2020·The New England Journal of Medicine·Victor G PuellesTobias B Huber
May 18, 2020·Kidney International·Jamie S HirschUNKNOWN Northwell Nephrology COVID-19 Research Consortium
May 18, 2020·The Lancet. Respiratory Medicine·Claudio RoncoFaeq Husain-Syed

❮ Previous
Next ❯

Citations

Mar 7, 2021·Journal of Clinical Medicine·Luis Sanchez-RussoPaolo Cravedi
May 1, 2021·Journal of Clinical Medicine·David LegouisFrédéric Sangla
Aug 8, 2021·International Journal of Molecular Sciences·Marta GłowackaJacek Rysz
Sep 18, 2021·Current Opinion in Nephrology and Hypertension·Daniel CottamLui G Forni

❮ Previous
Next ❯

Software Mentioned

Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Dialysis
Samsher SonawaneJeffrey S Berns
Clinical Journal of the American Society of Nephrology : CJASN
Santo MorabitoEnrico Fiaccadori
Læknablađiđ
Steinar Gudmundsson, Pall Torfi Onundarson
Revista da Associação Médica Brasileira
Erwin Otero GarcésFrancisco Verisimo Veronese
© 2021 Meta ULC. All rights reserved