Comparison of different biologic agents in patients with rheumatoid arthritis after failure of the first biologic therapy.

Wiener medizinische Wochenschrift
Christoph StrehblowPeter Fasching

Abstract

Switching between different biologic agents for the treatment of rheumatoid arthritis has become a common practice even within similar substance groups. This longitudinal observational study was performed to follow the therapeutic management of patients with rheumatoid arthritis who were switched from one biologic therapy to another. We found no differences between the different biologic agents in regard to drug survival respectively efficacy, neither in the first nor in the second course of therapy. The reason to switch (side effect, lack of efficacy or loss of efficacy) did not influence the following treatment, although a lack of efficacy showed the shortest drug survival in the subsequent therapy. In conclusion, while switching between different biologic substances in rheumatoid arthritis is feasible and reasonable, the choice of substance has to be made on an individual basis.

References

Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Sep 16, 2005·The New England Journal of Medicine·Mark C GenoveseMaxime Dougados
Mar 2, 2006·Arthritis Research & Therapy·Juan J Gomez-ReinoUNKNOWN BIOBADASER Group
May 17, 2007·Rheumatology·S BombardieriUNKNOWN Research in Active Rheumatoid Arthritis (ReAct) Study Group

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Citations

Jul 16, 2010·Wiener medizinische Wochenschrift·Peter Fasching

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