Comparison of different fractionation schedules toward a single fraction in high-dose-rate brachytherapy as monotherapy for low-risk prostate cancer using 3-dimensional radiobiological models

International Journal of Radiation Oncology, Biology, Physics
Panayiotis MavroidisDimos Baltas

Abstract

The aim of the present study was the investigation of different fractionation schemes to estimate their clinical impact. For this purpose, widely applied radiobiological models and dosimetric measures were used to associate their results with clinical findings. The dose distributions of 12 clinical high-dose-rate brachytherapy implants for prostate were evaluated in relation to different fractionation schemes. The fractionation schemes compared were: (1) 1 fraction of 20 Gy; (2) 2 fractions of 14 Gy; (3) 3 fractions of 11 Gy; and (4) 4 fractions of 9.5 Gy. The clinical effectiveness of the different fractionation schemes was estimated through the complication-free tumor control probability (P+), the biologically effective uniform dose, and the generalized equivalent uniform dose index. For the different fractionation schemes, the tumor control probabilities were 98.5% in 1×20 Gy, 98.6% in 2×14 Gy, 97.5% in 3×11 Gy, and 97.8% in 4×9.5 Gy. The corresponding P+ values were 88.8% in 1×20 Gy, 83.9% in 2×14 Gy, 86.0% in 3×11 Gy, and 82.3% in 4×9.5 Gy. With use of the fractionation scheme 4×9.5 Gy as reference, the isoeffective schemes regarding tumor control for 1, 2, and 3 fractions were 1×19.68 Gy, 2×13.75 Gy, and 3×11.05 Gy. The o...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Feb 11, 1998·International Journal of Radiation Oncology, Biology, Physics·D BaltasN Zamboglou
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuRupert Schmidt-Ullrich
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangX Allen Li
Mar 1, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·György KovácsHagen Bertermann
Feb 12, 2011·International Journal of Radiation Oncology, Biology, Physics·D Jeffrey DemanesGary Gustafson
May 10, 2011·International Journal of Radiation Oncology, Biology, Physics·Maroie BarkatiGillian M Duchesne
Jun 18, 2011·International Journal of Radiation Oncology, Biology, Physics·Peter HoskinHelen Cladd
Nov 18, 2011·The Journal of Urology·C Leland RogersJohn K Hayes
Aug 30, 2012·International Journal of Radiation Oncology, Biology, Physics·Nikolaos ZamboglouUlf W Tunn
Apr 2, 2013·Journal of Radiation Research·Yasuo YoshiokaKazuhiko Ogawa
Jun 4, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·G C Morton, P J Hoskin

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Citations

Jan 23, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mauro CarraraEmanuele Pignoli
Aug 3, 2014·Brachytherapy·Josh MasonAnn Henry
Mar 28, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·N TselisG Chatzikonstantinou

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