Comparison of different measures of urinary protein excretion for prediction of renal events.

Journal of the American Society of Nephrology : JASN
Hiddo J Lambers HeerspinkDick de Zeeuw

Abstract

There are many methods to screen for abnormal amounts of proteinuria to identify patients at risk for progression of renal disease, but which method best predicts renal risk is unknown. Here, we analyzed a subset of 701 patients with type 2 diabetes and nephropathy participating in the Reduction of Endpoints in Non Insulin Dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL) trial to compare the ability of urinary protein excretion (UPE) and urinary albumin excretion (UAE) from a 24-hour urine collection and urinary albumin concentration (UAC) and the albumin:creatinine ratio (ACR) from a first-morning void in predicting renal events. The primary outcome measure was the time to a doubling of serum creatinine or end-stage renal disease. During follow-up, 202 events occurred. The hazard ratios for the risk of a renal outcome (95% CIs) associated with 1-SD increment in the log-transformed measures were 3.16 (2.60 to 3.86) for UAE, 3.02 (2.53 to 3.62) for UPE, 3.23 (2.67 to 3.91) for UAC, and 4.36 (3.50 to 5.45) for ACR. The area under the ROC curve was significantly higher for ACR compared with the other measures. In conclusion, measurement of the albumin:creatinine ratio in a first-morning void is the ...Continue Reading

References

Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Jan 12, 2002·Kidney International·Henrik P HansenHans-Henrik Parving
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·B M BrennerUNKNOWN RENAAL Study Investigators
Jun 9, 2005·Archives of Disease in Childhood·J A EdgeUNKNOWN Youth and Family Advisory Committee of Diabetes UK
Aug 29, 2006·American Journal of Epidemiology·Ronald T GansevoortDick de Zeeuw
Sep 9, 2008·American Journal of Epidemiology·Hiddo J Lambers HeerspinkUNKNOWN PREVEND Study Group
Nov 26, 2008·Clinical Chemistry·W Greg MillerUNKNOWN National Kidney Disease Education Program-IFCC Working Group on Standardization of Albumin in Urine
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Elsbeth C WitteRonald Gansevoort
Feb 13, 2009·Journal of the American Society of Nephrology : JASN·Marije van der VeldeRonald T Gansevoort
May 16, 2009·Journal of the American Society of Nephrology : JASN·Toshiharu NinomiyaUNKNOWN ADVANCE Collaborative Group

❮ Previous
Next ❯

Citations

Aug 8, 2013·Zeitschrift für Rheumatologie·M JanneckC Iking-Konert
May 13, 2011·Nephron. Clinical Practice·Mark S MacGregor, Maarten W Taal
Jan 12, 2012·PloS One·Louise WatsonMichael W Beresford
Aug 3, 2011·Journal of the American Society of Nephrology : JASN·William F ClarkAmit X Garg
Mar 3, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Caitlin E CarterJoachim H Ix
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Blanche M ChaversRobert N Foley
Mar 4, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·DaoQi WuQiu Li
Sep 18, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Herrick FisherNisha Bansal
Apr 25, 2014·Kidney International·Sara S RoscioniDick de Zeeuw
Oct 14, 2011·Kidney International·William G CouserMarcello Tonelli
Jul 26, 2011·Advances in Chronic Kidney Disease·Gautham Viswanathan, Ashish Upadhyay
Jul 26, 2011·Advances in Chronic Kidney Disease·Mark J Sarnak, Brad C Astor
Jul 21, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Priya VartUNKNOWN PREVEND Study Group and the RENAAL Investigators
Jan 1, 2015·Nature Reviews. Disease Primers·Merlin C ThomasMark E Cooper
Sep 16, 2011·Journal of Clinical Laboratory Analysis·Rui LiuWen-Jie Pan
Jun 13, 2012·European Journal of Haematology·Sunil Bhandari, Renzo Galanello
Apr 8, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·J-J LiuUNKNOWN SMART2D study
Mar 31, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Yan-Feng ZhaoHong Zhang
Nov 1, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hee-Taik KangSang-Baek Koh
Aug 11, 2015·Clinical Proteomics·Marius A ØvrehusStein I Hallan
Jun 6, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Natalie EbertElke Schaeffner
Mar 14, 2014·International Journal of Vascular Medicine·Maria SambataroAngelo Paolo Dei Tos
Dec 4, 2014·Diabetes Research and Clinical Practice·Hans-Henrik ParvingPeter Rossing
Apr 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard J GlassockJ Stewart Cameron
May 28, 2011·Diabetes Care·David B SacksUNKNOWN Evidence-Based Laboratory Medicine Committee of the American Association for Clinical Chemistry
Mar 18, 2011·Diabetes Research and Clinical Practice·Helen SladeRobert J Walker
Sep 23, 2016·Clinical Journal of the American Society of Nephrology : CJASN·William HerringtonSarah Clark
Aug 1, 2015·European Journal of Preventive Cardiology·Bauke SchievinkHiddo J Lambers Heerspink
Feb 27, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marco van LondenMartin H de Borst

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.