Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
S SchuhJ Welzel

Abstract

To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight(®) , Callisto(®) and Skintell(®) . Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness of all skin layers was noted with Skintell(®) in contrast to VivoSight(®) and Callisto(®) . OCT comparisons revealed only slight differences between VivoSight(®) and Callisto(®) . Regarding BCC tumor thickness VivoSight(®) and Callisto(®) correlated well, histology did not correlate with the three OCT devices, whereas Skintell(®) showed no correlation with VivoSight(®) , Callisto(®) or histology. All tested OCT devices could identify BCCs and AKs objectively through standardized measurement of signal intensity and skin layer thickness. Due to their technical specifications (resolution, penetration dep...Continue Reading

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Citations

Feb 12, 2017·Photodiagnosis and Photodynamic Therapy·K B E FriisG B E Jemec
Feb 10, 2017·Photodiagnosis and Photodynamic Therapy·Luana NiculescuTanja von Braunmühl
Jun 5, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·F H Silver, R G Shah
Jun 13, 2018·Skin Pharmacology and Physiology·Sebastian BatzJürgen Lademann
May 1, 2019·Nature Biomedical Engineering·Dale J WaterhouseSarah E Bohndiek
Jan 21, 2020·Lasers in Surgery and Medicine·Mikaela KislevitzJeffrey Kenkel
Aug 5, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M UlrichG Pellacani
May 14, 2021·Ocular Oncology and Pathology·Sabrina BergeronMiguel N Burnier

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