Comparison of different optomotor response readouts for visual testing in experimental autoimmune encephalomyelitis-optic neuritis.

Journal of Neuroinflammation
Christina HeckerPhilipp Albrecht

Abstract

Optomotor response is increasingly used in preclinical research for evaluating the visual function in rodents. However, the most suitable measuring protocol for specific scientific questions is not always established. We aimed to determine the optimal parameters for visual function analysis in experimental autoimmune encephalomyelitis optic neuritis (EAEON), an animal model for multiple sclerosis. Contrast sensitivity as well as spatial frequency both had a low variance and a good test-retest reliability. Also, both parameters were able to differentiate between the EAEON and the control group. Correlations with the retinal degeneration, assessed by optical coherence tomography, the infiltration of immune cells, and the clinical disability score revealed that spatial frequency was superior to contrast sensitivity analysis. We therefore conclude that spatial frequency testing is better suited as visual acuity assessment in C57Bl/6 J EAEON mice. Furthermore, contrast sensitivity measurements are more time consuming, possibly leading to more stress for the animals.

References

Nov 24, 2004·Investigative Ophthalmology & Visual Science·Glen T PruskyRobert M Douglas
Nov 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·Kenneth S ShindlerAbdolmohamad Rostami
May 27, 2016·Neurology·Andrés Cruz-HerranzUNKNOWN IMSVISUAL consortium
Jan 29, 2019·Journal of Visualized Experiments : JoVE·Michael DietrichPhilipp Albrecht
Jan 30, 2019·Current Opinion in Neurology·Michael DietrichPhilipp Albrecht
Jul 19, 2019·Acta Neuropathologica Communications·Praveena ManogaranSven Schippling
Oct 17, 2019·Investigative Ophthalmology & Visual Science·Jiaxin XiaoKin-Sang Cho
Apr 16, 2020·Brain : a Journal of Neurology·Michael DietrichPhilipp Albrecht

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Software Mentioned

SPSS
EAEON
Heidelberg Eye [UNK]
Prims

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