Comparison of different regimens of human gonadotropins for superovulation of rhesus monkeys: ovulatory response and subsequent luteal function

Journal of in Vitro Fertilization and Embryo Transfer : IVF
Catherine A VandeVoortR L Stouffer

Abstract

This study was designed to identify suitable treatment regimens of human gonadotropin for superovulation of rhesus monkeys. At menses, female monkeys were given one of three regimens: Plan A [days 1 to 6, 60 IU human follicle-stimulating hormone (hFSH); days 7 to 9, 60 IU hFSH/60 IU human luteinizing hormone (hLH)], Plan B [days 1 to 3, 75 IU FSH/20 IU LH; days 4 to 6, 60 IU FSH/20 IU LH; days 7 to 9, 45 IU FSH/45 IU LH], or Plan C [days 1 to 9, 60 IU FSH/60 IU LH]. On day 10, human chorionic gonadotropin (hCG; 1000 IU) was administered. Serum estrogen levels peaked on the day of hCG treatment (day 10) in Plans A and C but earlier (day 8) in Plan B. An oviduct lavage recovered 1 to 3 oocytes in Plan B but 3 to 13 oocytes in the other treatment groups. Peak progesterone levels in the luteal phase were greater (P less than 0.05) in animals receiving Plan A or C than Plan B. Regardless of treatment group, progesterone levels declined abruptly 7 days after ovulation induction; the length of the luteal phase in all groups was significantly less than that of normal menstrual cycles. We conclude that regimens of hFSH and hLH (i.e., Plans A and C), followed by hCG, reliably superovulate rhesus monkeys. However, the premature decline in...Continue Reading

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Citations

Feb 19, 2008·Journal of Assisted Reproduction and Genetics·Jenna K Nyholt de Prada, Catherine A VandeVoort
Jan 9, 2003·Theriogenology·C A VandeVoortA F Tarantal
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M L HibbertM B Zelinski-Wooten
Mar 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jenna K Nyholt de PradaCatherine A VandeVoort
Feb 6, 2010·BMC Cell Biology·Chuti LaowtammathronAnthony W S Chan
Jun 18, 2004·Reproductive Biology and Endocrinology : RB&E·Richard L Stouffer, Mary B Zelinski-Wooten
Apr 6, 2006·Reproductive Biology and Endocrinology : RB&E·Hang YinRoger G Gosden
Sep 26, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Soon Ok KimDiane M Duffy
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Mar 30, 2007·Zygote : the Biology of Gametes and Early Embryos·N ChenS-C Ng

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