Comparison of different screening tools (FRAX®, OST, ORAI, OSIRIS, SCORE and age alone) to identify women with increased risk of fracture. A population-based prospective study

Bone
Katrine Hass RubinKim Brixen

Abstract

To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire concerning items on risk factors for osteoporosis. Fracture risk was calculated using the different screening tools (FRAX®, OST, ORAI, OSIRIS and SCORE) for each woman. The women were followed using the Danish National Register registering new major osteoporotic fractures during 3 years, counting only the first fracture per person. Area under the receiver operating characteristic curve (ROC) and statistics and Harrell's index were calculated. Agreement between the tools was calculated by kappa statistics. A total of 4% of the women experienced a new major osteoporotic fracture during the follow-up period. There were no differences in the area under the curve (AUC) values between FRAX® and the simpler tools; AUC values between 0.703 and 0.722 (p = 0.86). Also, Harrell's C values were very similar between the tools. Agreement between the tools was modest. During 3 years follow-up FRAX® did not perform better in the fracture risk pred...Continue Reading

References

Mar 1, 1989·American Journal of Public Health·J M MosseyR Craik
Aug 18, 1997·The American Journal of Medicine·O Johnell
Sep 29, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S M CadaretteT M Murray
Oct 3, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L K KohUNKNOWN Osteoporosis Self-Assessment Tool for Asians (OSTA) Research Group
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Aug 24, 2002·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·W B SedrineJ Y Reginster
Aug 26, 2003·Mayo Clinic Proceedings·Robert A AdlerValentina I Petkov
Nov 1, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O JohnellB Jönsson
Jan 2, 2004·QJM : Monthly Journal of the Association of Physicians·F RichyJ-Y Reginster
Jun 16, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Peter VestergaardLeif Mosekilde
May 11, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R B CookP Zioupos
Jun 30, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B RudB Abrahamsen
Feb 27, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisN Yoshimura
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Aug 30, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN National Osteoporosis Guideline Group
Jan 13, 2009·Maturitas·J CompstonUNKNOWN National Osteoporosis Guideline Group (NOGG)
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jesper RygPeter Vestergaard
Jul 28, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S K SandhuT V Nguyen
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduRoland D Chapurlat
Jul 14, 2010·Annals of Internal Medicine·Heidi D NelsonRoger Chou
Aug 5, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K H RubinK Brixen
Aug 20, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark J BollandIan R Reid
Oct 6, 2010·The Journal of Nutrition, Health & Aging·M J Bridges, S Ruddick
Feb 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Teresa A HillierSteven R Cummings
Aug 4, 2011·Scandinavian Journal of Public Health·Lau Caspar Thygesen, Annette Kjær Ersbøll
Sep 3, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Philip N SambrookStephen Gehlbach
Sep 8, 2011·Scandinavian Journal of Public Health·Lau Caspar ThygesenHenrik Brønnum-Hansen
Nov 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey

❮ Previous
Next ❯

Citations

Jun 13, 2015·Archives of Osteoporosis·M P HøibergG Haugeberg
Oct 6, 2015·Revista clínica española·J González-MacíasUNKNOWN en nombre de la Comisión de Redacción de las Guías de Osteoporosis de la SEIOMM
Mar 31, 2015·Journal of Diabetes and Metabolic Disorders·Nassim MatinMojgan Asadi
Jul 15, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W PluskiewiczB Drozdzowska
Oct 9, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Michael L WilczekTorkel B Brismar
Aug 19, 2015·Maturitas·Juliet Compston
Mar 11, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M IkiN Kurumatani
Jan 20, 2015·Orvosi hetilap·Viktória FerenczKatalin Bors
Dec 24, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Rafaela Martinez CopêsMelissa Orlandin Premaor
Apr 7, 2015·The Medical Clinics of North America·Anna L Golob, Mary B Laya
May 29, 2016·The Medical Clinics of North America·Kim M O'Connor
Jun 9, 2016·Computers, Informatics, Nursing : CIN·Carolina Pedrassani de LiraPriscyla Waleska Simões
Sep 7, 2016·Journal of the American Medical Directors Association·Pierpaolo PalumboDietrich Rothenbacher
Aug 3, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicolas BonnetSerge L Ferrari
Jun 21, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katrine Hass RubinBo Abrahamsen
Mar 29, 2019·Journal of Bone and Mineral Metabolism·On TakedaYasuyuki Ishibashi
May 9, 2014·Current Opinion in Rheumatology·William D Leslie, Suzanne N Morin
Jun 2, 2017·Clinical Oral Investigations·Wil GeraetsMagnus Hakeberg
Feb 6, 2017·Calcified Tissue International·Lapi FrancescoCricelli Claudio
Jul 3, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M HoffB Schei
Jan 19, 2019·Advances in Rheumatology·Bruna Aurora Nunes Cavalcante CastroMarcelo de Medeiros Pinheiro
Jun 28, 2018·JAMA : the Journal of the American Medical Association·Meera ViswanathanLeila C Kahwati
Mar 17, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C BeaudoinS Jean
Oct 29, 2020·Archives of Osteoporosis·William D LeslieNeil Binkley
Apr 23, 2021·International Urology and Nephrology·Betul CetinEbru Asicioglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
J TamakiH Yoneshima
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
William D LeslieJohn A Kanis
Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
William D LeslieManitoba Bone Density Program
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
William D LeslieManitoba Bone Density Program
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Margaret L GourlayStudy of Osteoporotic Fractures Research Group
© 2021 Meta ULC. All rights reserved