Comparison of different settings for yellow subthreshold laser treatment in diabetic macular edema

BMC Ophthalmology
Jay ChhablaniAnnie Mathai

Abstract

To assess the safety and efficacy of two subthreshold parameters (5 and 15% duty cycle (DC)) compared to standard ETDRS (early treatment of diabetic retinopathy study) continuous wave (CW) laser. In this prospective randomized study, 30 eyes from 20 patients with non-center involving macular edema were randomized into 3 different groups: 5% DC, 15% DC and CW navigated modified ETDRS laser treatment. Titration in subthreshold groups was performed with 30% of the threshold power, decided with microsecond pulses. CW laser was titrated to a barely visible burn. All patients underwent microperimetry, thickness measurements and visual acuity examinations at baseline, 6 weeks and 12 weeks post treatment. At three months follow up, retinal sensitivity was significantly reduced in the CW group by - 2.2 dB whereas in both subthreshold groups, retinal sensitivity increased by 2.4 dB for 5% and 1.9 dB for 15% DC with no significant difference. Retinal volume (mm3) decreased in both subthreshold groups by 0.08 ± 0.3 and 0.12 ± 0.11 in 5 and 15% DC group respectively. Whereas the CW group showed volume increase of 0.55 ± 0.92 (p = 0.02 and 0.01 for 5 and 15% DC groups). Visual acuity remained stable in all 3 groups (- 0.7 letter in 5% DC; 2....Continue Reading

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Citations

Feb 20, 2019·Journal of Clinical Medicine·Maciej Gawęcki
Jan 11, 2020·Frontiers in Endocrinology·Stephen H Sinclair, Stanley S Schwartz
Feb 2, 2021·Therapeutic Advances in Ophthalmology·Diego Alejandro Valera-CornejoRenata García-Franco
Jan 11, 2021·International Journal of Retina and Vitreous·Renato M PassosMichel E Farah
Jun 3, 2021·Journal of Personalized Medicine·Luisa FrizzieroEdoardo Midena
Sep 4, 2020·Current Drug Safety·Tobias P H NissenKristian Aasbjerg

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