Comparison of different water/oil microemulsions containing diclofenac sodium: preparation, characterization, release rate, and skin irritation studies

AAPS PharmSciTech
Gülten KantarciTamer Güneri

Abstract

The aim of the present study was to make a comparison of the in vitro release rate of diclofenac sodium (DS) from microemulsion (M) vehicles containing soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols (ethanol [E], isopropyl alcohol [I], and propanol [P]) as cosurfactant. The optimum surfactant:cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of phase diagrams. Three microemulsion formulations were selected, and their physicochemical properties were examined for the pH, viscosity, and conductivity. According to the release rate of DS, M prepared with P showed the significantly highest flux value (0.059 +/- 0.018 mg/cm(2)/h) among all formulations (P < .05). The conductivity results showed that DS-loaded microemulsions have higher conductivity values (18.8-20.2 microsiemens/cm) than unloaded formulations (16.9-17.9 microsiemens/cm), and loading DS into the formulation had no negative effect on system stability. Moreover, viscosity measurements were examined as a function of shear rate, and Newtonian fluid characterization was observed for each microemulsion system. All formulations had appropriate observed pH values varying from 6.70 to 6.85 for topical applicatio...Continue Reading

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Citations

Sep 17, 2009·AAPS PharmSciTech·Adnan AzeemSushama Talegaonkar
Feb 2, 2013·International Journal of Pharmaceutical Investigation·Vidya Sabale, Sejal Vora
Sep 9, 2010·AAPS PharmSciTech·Magda R A FerreiraLuiz A L Soares
Sep 4, 2015·Pharmaceutical Development and Technology·Mrunali Rashmin PatelBharat G Patel
Jun 11, 2010·Pharmaceuticals·Bindu Nair, Regina Taylor-Gjevre
Feb 26, 2013·Journal of Pharmaceutical Sciences·Dominique PepeLuciana B Lopes
May 8, 2013·The Journal of Pharmacy and Pharmacology·Allie CichewiczLuciana B Lopes
Jul 3, 2015·Drug Development and Industrial Pharmacy·Maha Nasr, Sameh Abdel-Hamid
Oct 21, 2016·AAPS PharmSciTech·Vanessa F CarvalhoLuciana B Lopes
Sep 17, 2015·Anais Da Academia Brasileira De Ciências·Muhammad NaeemMuhammad K Sarfraz

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