Comparison of digitalis-related adverse events in hospitalized men and women in Italy: an observational study

Clinical Therapeutics
Claudio PedoneGIFA Investigators

Abstract

A higher mortality rate in women than in men treated with digitalis has been described. We hypothesized that this result could be due in part to an increased susceptibility of women to adverse events (AEs) from digitalis. The aim of this study was to compare the incidence of AEs related to digitalis in women and men. This was an observational study conducted in geriatrics and internal medicine acute-care wards located throughout Italy. We used the data of the Gruppo Italiano di Farmacoepidemiologia nell'Anziano (Italian Group of Pharmacoepidemiology in the Elderly), a collaborative study group on drug use and adverse drug reactions in hospitalized adults that performed 6 different surveys between 1988 and 1998. Adults who were taking digitalis at the time of admission or during the hospital stay were studied, with no other inclusion or exclusion criteria. The proportion of AEs to digitalis diagnosed at the time of admission or during the hospital stay was compared in men and women. Information on AEs was collected using a structured questionnaire at admission and during the hospital stay. A logistic regression model was used to evaluate the association between sex and AE(s) to digitalis, corrected for potential confounding vari...Continue Reading

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Citations

May 31, 2012·Drugs & Aging·Antonio CherubiniFabrizia Lattanzio
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fabrizia LattanzioAndrea Corsonello
May 31, 2011·Journal of the American Medical Directors Association·Antonio CherubiniCarmelinda Ruggiero
Apr 8, 2015·Journal of Evaluation in Clinical Practice·Carmen Guadalupe Rodriguez-GonzalezUNKNOWN iPharma

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