Comparison of Disease Phenotypes and Clinical Characteristics Among South Asian and White Patients with Inflammatory Bowel Disease at a Tertiary Referral Center.

Inflammatory Bowel Diseases
Vimal BodiwalaDarren N Seril

Abstract

The prevalence and clinical features of inflammatory bowel disease (IBD) vary among different racial and ethnic groups. The aim of this study was to compare the clinical and phenotypic features of Crohn's disease (CD) and ulcerative colitis (UC) in South Asian patients living in the United States with those of a white cohort. The demographic, clinical, and phenotypic characteristics of 73 South Asian patients (31 CD and 42 UC) who presented initially to our tertiary referral center from 2012 to 2016 and had subsequent follow-up were retrospectively compared with those of 408 consecutive white patients (245 CD and 163 UC). South Asian IBD patients were significantly more likely to have UC (58.0% vs 40.0%; P = 0.005) than white patients. South Asians with CD were less likely to have a family history of IBD (9.7% vs 26.9%; P = 0.037) and required fewer CD-related surgeries (22.5% vs 46.1; P = 0.012). South Asians were also less likely to be active or former smokers in both the CD (P = 0.004) and UC (P = 0.020) groups. South Asians with UC had a higher incidence of Clostridium difficile infection compared with white patients (19.0% vs 8.6%; P = 0.050). A cohort of South Asian patients with IBD were more likely to have UC and had di...Continue Reading

References

Nov 1, 1975·Journal of Medical Microbiology·J A van der Wiel-Korstanje, K C Winkler
Feb 24, 2001·Scandinavian Journal of Gastroenterology·F FarrokhyarE J Irvine
Aug 23, 2001·Inflammatory Bowel Diseases·S K YangW J Sandborn
Feb 8, 2002·World Journal of Gastroenterology : WJG·Xue-Liang Jiang, Hui-Fei Cui
Feb 13, 2008·Inflammatory Bowel Diseases·Suhal S MahidSusan Galandiuk
Aug 15, 2008·Journal of Clinical Microbiology·Stephan J OttStefan Schreiber
Sep 5, 2008·Digestive Diseases and Sciences·Kshaunish DasGovind K Makharia
Dec 18, 2008·The American Journal of Gastroenterology·Kelvin T ThiaSuk-Kyun Yang
May 28, 2009·The American Journal of Gastroenterology·Jason K HouSelvi Thirumurthi
Sep 24, 2010·Journal of Clinical Microbiology·Ravi VermaJaishree Paul
May 18, 2011·The American Journal of Gastroenterology·David G WalkerTimothy R Orchard
Sep 4, 2012·Journal of Crohn's & Colitis·Saurabh MukewarBo Shen
Oct 18, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Govind K MakhariaUNKNOWN Indian Society of Gastroenterology Task Force on Inflammatory Bowel Disease
Apr 16, 2013·Gastroenterology·Siew C NgUNKNOWN Asia–Pacific Crohn's and Colitis Epidemiologic Study (ACCESS) Study Group
Aug 2, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Reenu MalhotraRobert M Genta
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Mar 11, 2015·The American Journal of Gastroenterology·Eric I BenchimolDouglas G Manuel
Aug 3, 2016·The American Journal of Gastroenterology·Natalie ToAlexander C Ford
Oct 1, 2016·World Journal of Gastroenterology : WJG·Gautam Ray
May 6, 2017·Journal of Gastroenterology and Hepatology·Umang AroraVineet Ahuja
Jun 5, 2018·Digestive Diseases and Sciences·Peiqi WangSusan M Hutfless
Jul 19, 2018·Inflammatory Intestinal Diseases·Saurabh Kedia, Vineet Ahuja
May 17, 2019·Inflammatory Bowel Diseases·Kian KeyashianK T Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.