Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents

Drug and Alcohol Review
Helmut Niederhofer, Wolfgang Staffen

Abstract

About 50% of alcoholic patients relapse within 3 months of treatment. Previous studies have suggested that disulfiram may help to prevent such relapse. The aim of our study was to assess the efficacy and safety of long-term disulfiram treatment in alcohol dependence of adolescents. In this double-blind, placebo-controlled study we recruited 26 adolescents, aged 16-19 years, with chronic or episodic alcohol dependence. Patients were allocated treatment randomly with disulfiram (200 mg daily) or placebo for 90 days. Patients were assessed on the day treatment started and on days 30 and 90 by interview, self-report, questionnaire and laboratory screening. Patients were classified as abstinent, relapsing or non-attending. Time to first treatment failure (relapse or non-attendance) was the primary outcome measure. The disulfiram (n=13) and placebo (n=13) groups were well matched in terms of baseline demographic and alcohol-related variables. Thirteen disulfiram-treated and 13 placebo-treated patients completed the treatment phase; seven (1 vs. 6) relapsed, five (3 vs. 2) refused to continue treatment, three (1 vs. 2) had concurrent illness and two (1 vs. 1) had adverse side effects. At the end of treatment, seven disulfiram-treated ...Continue Reading

References

Aug 1, 1992·Alcoholism, Clinical and Experimental Research·L GallimbertiG L Gessa
Nov 1, 1992·Archives of General Psychiatry·J R VolpicelliC P O'Brien
Nov 1, 1992·Archives of General Psychiatry·S S O'MalleyB Rounsaville
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·M DaoustP Durbin
Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J P LhuintreF Boismare
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·K A Grant, W L Woolverton
Aug 1, 1983·Acta Psychiatrica Scandinavica·V Borg
Oct 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·G K ShawG Dunn
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·B J MasonE Mantero-Atienza
Mar 1, 1995·The American Journal of Psychiatry·H R KranzlerN Liebowitz
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·E M SellersM B Sobell
May 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·W C MyersM R Goldstein

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Citations

Jul 26, 2008·Current Psychiatry Reports·Christopher A LampsRishi Sood
Nov 3, 2005·Journal of Child and Adolescent Psychopharmacology·James G Waxmonsky, Timothy E Wilens
Sep 19, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·P AguiarP Ferrinho
Feb 13, 2014·PloS One·Marilyn D SkinnerHenri-Jean Aubin
Jun 9, 2012·CNS Drugs·Duncan B Clark
Aug 17, 2011·International Journal of Environmental Research and Public Health·Angelo Giovanni Icro MaremmaniIcro Maremmani
Mar 25, 2011·Indian Journal of Psychiatry·Princy Louis Palatty, Elroy Saldanha
Jan 25, 2014·Expert Opinion on Pharmacotherapy·Christian A MüllerAndreas Heinz
Feb 2, 2011·Pediatric Clinics of North America·Gabriel Kaplan, Iliyan Ivanov
Aug 5, 2010·Child and Adolescent Psychiatric Clinics of North America·Deborah R Simkin, Severin Grenoble
Nov 20, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Francheska PerepletchikovaJoan Kaufman
May 28, 2011·Alcoholism, Clinical and Experimental Research·Charlotte H JørgensenHanne Tønnesen
Oct 15, 2013·Alcoholism, Clinical and Experimental Research·Atsushi YoshimuraSusumu Higuchi
Sep 27, 2014·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Maria PainoPaul M Roman
Mar 30, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Julia M A SinclairDavid S Baldwin
Jul 26, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Christopher J KratochvilTimothy E Wilens
May 18, 2016·The American Journal of Drug and Alcohol Abuse·Michael P BogenschutzJ Scott Tonigan
Jun 25, 2016·Child and Adolescent Psychiatric Clinics of North America·Cecilia Patrica Margret, Richard K Ries
Aug 4, 2016·Neurotoxicity Research·Patrycja KleczkowskaMagdalena Bujalska-Zadrozny
Sep 11, 2016·Child and Adolescent Psychiatric Clinics of North America·Christopher J Hammond
May 26, 2012·Journal of Psychopharmacology·A R Lingford-HughesUNKNOWN British Association for Psychopharmacology, Expert Reviewers Group
Jan 14, 2017·Journal of Child & Adolescent Substance Abuse·Christopher J Hammond, Kevin M Gray
Aug 15, 2018·Neuropsychopharmacology Reports·Nagisa SugayaKazutaka Ikeda
Aug 1, 2015·World Journal of Gastroenterology : WJG·María Luisa Gutiérrez GarcíaConrado M Fernández-Rodríguez
May 14, 2016·Deutsches Ärzteblatt International·Anil BatraAndreas Heinz
Feb 13, 2021·Journal of Health Economics·Sarah Hamersma, Johanna Catherine Maclean
Mar 30, 2021·Frontiers in Cellular and Infection Microbiology·Debbie-Ann ShirleyShannon Moonah

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