Comparison of doxorubicin anticancer drug loading on different metal oxide nanoparticles

Medicine
Khalid Rashid JavedAbubakar Shahid

Abstract

Nanomaterials are being vigorously investigated for their use in anticancer drug delivery regimes or as biomarkers agents and are considered to be a candidate to provide a way to combat severe weaknesses of anticancer drug pharmacokinetics, such as their nonspecificity. Because of this weakness, a bigger proportion of the drug-loaded nanomaterials flow toward healthy tissues and result in undesirable side effects. It is very important to evaluate drug loading and release efficiency of various nanomaterials to find out true pharmacokinetics of these drugs.This observational study aims to evaluate various surface functionalized and naked nanomaterials for their drug loading capability and consequently strengthens the Reporting of Observational Studies in Epidemiology (STROBE). We analyzed naked and coated nanoparticles of transition metal oxides for their further loading with doxorubicin, a representative water-soluble anticancer drug.Various uncoated and polyethylene glycol-coated metal oxide nanoparticles were synthesized and loaded with anticancer drug using simple stirring of the nanoparticles in a saturated aqueous solution of the drug. Results showed that surface-coated nanoparticles have higher drug-loading capabilities; h...Continue Reading

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Citations

Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tuğba SağirSevim Isık
Feb 18, 2018·Drug Development and Industrial Pharmacy·Nahid PoorgholyHamed Hamishehkar
Sep 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Neha KarkiNanda Gopal Sahoo
Nov 5, 2020·Nanotoxicology·Dominik TaterraKrzysztof A Tomaszewski
Dec 28, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Bichitra Nandi GangulyRohit Kumar Rana

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Methods Mentioned

BETA
x-ray diffraction

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