PMID: 9426082Jan 13, 1998Paper

Comparison of drug delivery from conventional versus "Venturi" nebulizers

The European Respiratory Journal
S G DevadasonP N Le Souef

Abstract

Attempts to improve drug delivery from conventional jet nebulizers have included the use of storage systems to reduce drug wastage during exhalation. Venturi nebulizers enhance drug delivery during inhalation, reducing treatment times and drug wastage. This study investigated the effect of age on inhaled dose from a conventional jet nebulizer (Acorn) used both with and without a storage chamber (Mizer), compared to two Venturi nebulizers (Ventstream and Pari LC). Filters were attached to the four nebulizer systems, containing salbutamol, and 18 children with cystic fibrosis (3-16 yrs) inhaled through these devices. The quantity of drug collected on the filter was assessed using ultraviolet spectrophotometry. The particle size distribution of the aerosol from each nebulizer system was measured using laser diffraction. Inspiratory filter deposition using the Acorn was lower than the Acorn with Mizer, and both Venturi nebulizers. Filter deposition using the Acorn with Mizer was lower than the Pari LC. No trend with age, height or weight was noted using any nebulizer. Aerosol particle size using the Ventstream was lower than the other nebulizer systems. Drug output from both Venturi nebulizers was more efficient than from the jet n...Continue Reading

Citations

Apr 14, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Lucy E A Hardaker, Ross H M Hatley
Aug 10, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·T A StandaertB Ramsey
Oct 25, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·P N Le Souef, S G Devadason
Oct 25, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·T E CorcoranA T Iacono
Sep 27, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Y ZhouY S Cheng
Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A M MünsterJ Gram
Mar 21, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A L CoatesL C Lands
May 12, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·André SchultzSunalene G Devadason
Jan 5, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·L PitanceL Vecellio
Oct 3, 1999·Allergy·L Di Berardino, F Scaglione
Jul 28, 1999·Allergy·P Le Souëf
May 2, 2013·The Cochrane Database of Systematic Reviews·Tracey DanielsPaul Whitaker
Mar 21, 2009·Expert Review of Medical Devices·Jolyon P Mitchell, Mark W Nagel
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·K E BendstrupM T Newhouse
May 27, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Matthew WilkinsonCoburn Allen

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