Abstract
The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for hepatic cryoablation in a porcine model. Eighteen cryoablations were performed over an exposed operation field in nine normal porcine livers, using dual- (10-5-10-5) and triple-freeze (5-5-5-5-10-5) protocols. Changes in the temperature of the cryoprobes and the diameter of the iceballs were recorded during the ablation, and pathological changes in the cryozones (zones of tissue destruction) were assessed seven days after the procedure. Use of two and three freeze-thaw cycles produced iceballs of different diameters. Seven days after cryosurgery, the triple-freeze protocol was associated with a larger zone of complete necrosis than the dual-freeze protocol, although the two protocols produced cryozones and cryolesions of similar length, and in both cases the cryozones contained five areas of destruction. With the same freezing time (20 min), the triple-freeze protocol may be a more powerful liver ablation method than the dual-freeze protocol.
References
Dec 16, 1975·British Dental Journal·D K Whittaker
Apr 1, 1985·Cryobiology·A A GageD A Whalen
May 1, 1967·The Journal of Trauma·J C FishW J Holaday
Oct 1, 1984·The Journal of Dermatologic Surgery and Oncology·S M BurgeR P Dawber
Mar 11, 1998·Seminars in Surgical Oncology·X D Zhou, Z Y Tang
Nov 1, 1955·Cancer·P SERRA, A BRUNSCHWIG
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Nov 20, 2004·Radiology·Peter J LittrupWael Sakr
Feb 16, 2005·Cryobiology·Valérie ForestJean-Michel Vergnon
May 17, 2005·BJU International·John G Baust, Andrew A Gage
Jan 28, 2006·Cell·John Condeelis, Jeffrey W Pollard
Aug 15, 2006·Current Treatment Options in Oncology·Cletus A Arciero, Elin R Sigurdson
Mar 23, 2007·Journal of Vascular and Interventional Radiology : JVIR·Peter J LittrupLance K Heilbrun
Nov 15, 2008·Cryobiology·Michael S Sabel
Aug 22, 2009·Journal of Vascular and Interventional Radiology : JVIR·Peter J LittrupDonald Herring
Oct 17, 2009·Cryobiology·A A GageJ G Baust
Apr 8, 2010·Cell·Bin-Zhi Qian, Jeffrey W Pollard
May 4, 2010·Cardiovascular and Interventional Radiology·J Louis HinshawChristopher L Brace
Nov 26, 2010·International Journal of Surgery·H W ChenWan Yee Lau
Jul 5, 2011·Nature Medicine·Qian HuangChuan-Yuan Li
Citations
Aug 6, 2013·Cryobiology·Zhang ZhikaiXu Kecheng
Dec 26, 2013·Cryobiology·Zhou LiangXu Kecheng
Jul 13, 2013·Cryobiology·Zhikai ZhangKecheng Xu
Jan 28, 2014·Cryobiology·Jiongyuan XuKecheng Xu