PMID: 9548195Apr 21, 1998Paper

Comparison of dual-isotope acquisition of 201Tl and 99Tcm-tetrofosmin for the detection of ischaemic heart disease and determination of the optimal imaging time of 99Tcm-tetrofosmin

Nuclear Medicine Communications
Y ItoT Nishimura

Abstract

Comparative studies of thallium-201 (201Tl) and 99Tcm-tetrofosmin for the detection of ischaemic heart disease (IHD) have previously been reported. These 201Tl and 99Tcm-tetrofosmin studies were usually performed separately with different exercise loads at an interval of several days. Here, we used a dual-isotope technique with exercise myocardial SPET (single photon emission tomography) in 17 patients with IHD and 10 patients with normal coronary arteries. The triple-energy window (TEW) method was applied for cross-talk correction. SPET imaging was performed at 10 and 70 min (S1 and S2) after the injection of 99Tcm-tetrofosmin (222 MBq) and 201Tl (74 MBq) at peak exercise to determine the optimal imaging time of 99Tcm-tetrofosmin. The S2 value was obtained 35 min after the subject drank a glass of milk to accelerate hepatobiliary clearance. Twenty-five minutes after S2, 37 MBq of 201Tl were reinjected at rest and SPET imaging (S3) was performed. Immediately after S3, 666 MBq of 99Tcm-tetrofosmin were reinjected and SPET imaging (S4) was performed 50 min later. Representative short and vertical long axis tomograms were divided into 17 segments. Each segment was assessed using a 4-point scoring system. The defect score was defin...Continue Reading

Citations

Dec 17, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Assuero GiorgettiPaolo Marzullo
Nov 11, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Laurent PhilippeGuillaume Divry
Feb 21, 2004·International Journal of Cardiology·Yasushi AkutsuTakashi Katagiri
Apr 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Simona Ben-HaimPeter J Ell

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