Comparison of dual-time point 18F-FDG PET/CT tumor-to-background ratio, intraoperative 5-aminolevulinic acid fluorescence scale, and Ki-67 index in high-grade glioma

Medicine
Yong-Il KimSu Jin Jang

Abstract

The aim of this study was to compare preoperative dual-time point F-fluorodeoxyglucose (FDG) uptake pattern with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in high-grade gliomas. In addition, we assessed for possible associations with a pathologic parameter (Ki-67 index).Thirty-one patients with high-grade glioma (M:F = 19:12, mean age = 60.6 ± 11.2 years) who underwent dual-time point F-FDG positron emission tomography (PET)/computed tomography (CT) scan before surgery were retrospectively enrolled; 5-ALA was applied to the surgical field of all these patients and its fluorescence intensity was evaluated during surgery. Measured F-FDG PET/CT parameters were maximum and peak tumor-to-background ratio (maxTBR and peakTBR) at base (-base) and delayed (-delay) scan. The intensity of 5-ALA fluorescence was graded on a scale of three (grade I as no or mild intensity, grade II as moderate intensity, and grade III as strong intensity).Seven of the patients had WHO grade III brain tumors and 24 had WHO grade IV tumors (mean tumor size = 4.8 ± 1.8 cm). MaxTBR-delay and peakTBR-delay showed significantly higher values than maxTBR-base and peakTBR-base, respectively (all P < .001). Among the F-FDG PET/CT parameters, only ma...Continue Reading

References

Jun 1, 1985·Journal of Neurosurgery·N J PatronasS M Larson
Jan 1, 1987·Acta Neuropathologica·F GiangasperoH Stein
Jul 1, 1995·The Journal of Investigative Dermatology·J A RamsayH J Kahn
Jul 7, 2001·European Journal of Nuclear Medicine·K KubotaH Fukuda
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Paul KleihuesWebster K Cavenee
Oct 16, 2003·Journal of Neuro-oncology·M V PadmaJ C Mantil
Oct 22, 2003·Nuclear Medicine Communications·G R Conrad, P Sinha
Mar 9, 2005·Nuclear Medicine Communications·Wan-Yu LinGuang-Uei Hung
Sep 15, 2005·Nuclear Medicine Communications·Yoshihiro NishiyamaMotoomi Ohkawa
Jul 20, 2007·Lancet Neurology·Karl HerholzAlan Jackson
Feb 20, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Ruoh-Fang YenYung-Chie Lee
Feb 22, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James W FletcherAnthony F Shields
Sep 2, 2009·Nuclear Medicine and Biology·Dirk PauleitKarl-Josef Langen
May 19, 2010·Clinical Nuclear Medicine·Dae-Weung KimSoon-Ah Park
May 17, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elena PrietoJavier Arbizu
Sep 11, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Michael J Colditz, Rosalind L Jeffree
Oct 13, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Michael J ColditzRosalind L Jeffree

❮ Previous
Next ❯

Citations

Jun 26, 2021·Pathology, Research and Practice·Seyed Hamed JafariMajid Nejati
Aug 17, 2021·Frontiers in Oncology·Barbara KieselGeorg Widhalm

❮ Previous
Next ❯

Software Mentioned

MedCalc
SPSS
Syngo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved