Comparison of early quality of life in patients treated with radiotherapy following mastectomy or breast conservation therapy: a prospective study

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Anusheel MunshiRajendra A Badwe

Abstract

To compare quality of life (QOL) in breast cancer patients from a developing country after breast conservation surgery (BCS) or mastectomy and adjuvant radiotherapy (RT). In a 6-month period, all consecutive early and locally advanced breast cancer patients treated with either BCS or mastectomy and treated with RT were analyzed. All patients who underwent mastectomy were treated with 45 Gray/20#/4 weeks. Patients with BCS were treated with a dose of 45-50 Gray/25#/5 weeks to whole breast followed by tumor bed boost (15 Gray/6#/6 days with suitable energy electrons). Prospective evaluation of QOL using EORTC QLQ C30 and breast cancer specific QLQ BR23 was done before starting RT (baseline), at mid-RT and at RT conclusion for all patients. One hundred and thirteen patients had mastectomy and 142 patients underwent BCS. Reliability test (Cronbach alpha) for questionnaire filling was 0.669-0.886. At pre-RT assessment, global QOL scores in mastectomy and BCS groups were 71.1 and 71.3, respectively. There was no significant difference in pre-RT EORTC QLQ C30 functional and symptom domains between mastectomy and BCS patients. However, social function domain score was higher in patients who underwent mastectomy (83 versus 73.9; p=0.018...Continue Reading

References

Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel PolskyKevin A Schulman
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HärtlM Stauber
Aug 5, 2006·Japanese Journal of Clinical Oncology·Manoj PandeyKuttan Ratheesan
Jan 11, 2007·International Journal of Cancer. Journal International Du Cancer·Umberto Veronesi, Stefano Zurrida
Apr 22, 2008·Journal of Anxiety Disorders·Melissa M NorbergDavid F Tolin
May 28, 2008·Journal of Cancer Research and Clinical Oncology·Volker ArndtHermann Brenner
Aug 1, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Juan Ignacio ArrarasEsteban Salgado
Nov 28, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V PeuckmannM Groenvold
Apr 22, 2009·Qualitative Health Research·Julie B SchnurGuy H Montgomery

❮ Previous
Next ❯

Citations

Oct 14, 2017·Journal of the National Cancer Institute·Vivek VermaMark V Mishra
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Peerawong ThanarpanPuttawibul Puttisak
May 14, 2020·Health and Quality of Life Outcomes·Krzysztof Adamowicz, Zuzanna Baczkowska-Waliszewska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Kathryn J Ruddy, Ann H Partridge
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Wenchi LiangJeanne S Mandelblatt
© 2021 Meta ULC. All rights reserved