Comparison of Early Versus Delayed Oral β Blockers in Acute Coronary Syndromes and Effect on Outcomes

The American Journal of Cardiology
Raffaele BugiardiniLina Badimon

Abstract

The aim of this study was to determine if earlier administration of oral β ​blocker therapy in patients with acute coronary syndromes (ACSs) is associated with an increased short-term survival rate and improved left ventricular (LV) function. We studied 11,581 patients enrolled in the International Survey of Acute Coronary Syndromes in Transitional Countries registry from January 2010 to June 2014. Of these patients, 6,117 were excluded as they received intravenous β blockers or remained free of any β ​blocker treatment during hospital stay, 23 as timing of oral β ​blocker administration was unknown, and 182 patients because they died before oral β blockers could be given. The final study population comprised 5,259 patients. The primary outcome was the incidence of in-hospital mortality. The secondary outcome was the incidence of severe LV dysfunction defined as an ejection fraction <40% at hospital discharge. Oral β blockers were administered soon (≤24 hours) after hospital admission in 1,377 patients and later (>24 hours) during hospital stay in the remaining 3,882 patients. Early β ​blocker therapy was significantly associated with reduced in-hospital mortality (odds ratio 0.41, 95% CI 0.21 to 0.80) and reduced incidence of ...Continue Reading

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Citations

Jul 4, 2016·International Journal of Cardiology·Emir FazlibegovićMustafa Hadziomerovic
Jul 6, 2016·International Journal of Cardiology·Marlous HallChris P Gale
Jul 9, 2016·International Journal of Cardiology·Raffaele BugiardiniUNKNOWN ISACS-TC Investigators and Coordinators
Jul 11, 2016·International Journal of Cardiology·Zorana Vasiljevic-PokrajcicRaffaele Bugiardini
Jul 7, 2016·International Journal of Cardiology·Olivia ManfriniUNKNOWN ISACS-TC Investigators
Jul 7, 2016·International Journal of Cardiology·Božidarka KneževićMilovan Kalezić
Jul 10, 2016·International Journal of Cardiology·Robert HalmosiKalman Toth
Aug 16, 2016·International Journal of Cardiology·Edina CenkoRaffaele Bugiardini
Aug 11, 2016·International Journal of Cardiology·Beatrice RicciRaffaele Bugiardini
Aug 26, 2016·International Journal of Cardiology·Maria Dorobantu, Stefan Bogdan
Sep 2, 2017·Journal of the American Heart Association·Raffaele BugiardiniLina Badimon
Dec 24, 2017·Journal of the American Heart Association·Beatrice RicciRaffaele Bugiardini
Nov 15, 2019·Critical Pathways in Cardiology·Michael I BrenerLeRoy E Rabbani

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