Comparison of effectiveness and safety of drug-eluting stents versus vascular brachytherapy for saphenous vein graft in-stent restenosis

The American Journal of Cardiology
Sundeep MishraRon Waksman

Abstract

We investigated the safety and efficacy of drug-eluting stents (DESs) for the treatment of patients who presented with in-stent restenosis (ISR) of saphenous vein grafts (SVGs) and compared the in-hospital and 6-month clinical outcomes of DESs with those of intravascular brachytherapy and balloon angioplasty alone. Records of 187 patients who presented with ISR of SVGs were analyzed. Of these, 34 consecutive patients were treated with DES implantation, 93 were treated with intravascular brachytherapy (n = 60 with gamma-radiation, n = 33 with beta-radiation), and 60 patients underwent conventional treatment with balloon angioplasty alone. Clinical and angiographic characteristics at baseline were comparable between groups. The DES group had less non-Q-wave myocardial infarction than did the intravascular brachytherapy and balloon angioplasty groups (0%, 20%, and 26%, p = 0.003 and <0.001, respectively). At 6 months, death occurred in 0% of the DES group, 2% of the intravascular brachytherapy group, and 5% of the balloon angioplasty group (p = 0.36 and <0.18, respectively). Target lesion revascularization/major adverse cardiac events were similar in the intravascular brachytherapy and DES groups (12% and 3%, p = 0.13) and signifi...Continue Reading

References

Apr 19, 2002·The New England Journal of Medicine·Ron WaksmanJoseph Lindsay
Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Subir NagVictor Levin
Jan 28, 2003·Lancet·Rossella Fattori, Tommaso Piva
Jul 31, 2003·The American Journal of Cardiology·Gregg W StoneUNKNOWN SVG BRITE Investigators
Oct 27, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gerald S WernerHans R Figulla
Dec 9, 2004·JAMA : the Journal of the American Medical Association·Diego ArdissinoUNKNOWN SES-SMART Investigators
Dec 21, 2004·Journal of the American College of Cardiology·Gerald S WernerHans R Figulla
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Adnan KastratiUNKNOWN ISAR-DESIRE Study Investigators
Mar 24, 2005·JAMA : the Journal of the American Medical Association·James D Flaherty, Charles J Davidson

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Citations

Dec 6, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·J WöhrleV Hombach
Aug 30, 2008·The American Journal of Cardiology·Teruo OkabeRon Waksman
Jan 6, 2012·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·S N GoyalD S Arya

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