PMID: 590224Dec 1, 1977

Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges

Epilepsia
E D Bigler

Abstract

The effects of bicuculline, strychnine, and picrotoxin on photically evoked afterdischarges (PhADs) in rat visual cortex were compared with those of pentylenetetrazol (a known PhAD potentiator) and a diazepam (a known PhAD suppressor) challenge. Bicuculline was found to augment PhADs in a manner similar to that found with pentylenetetrazol, with the exception that potentiation only occurred at convulsive levels whereas pentylenetetrazol augmentation occurred at both subconvulsive and convulsive levels. Diazepam suppressed bicuculline-potentiated PhADs. Picrotoxin was found to have some limited augmenting effect on PhAD activity but in a manner unlike that observed with either bicuculline or pentylenetetrazol. Strychnine had no systematic augmenting effect on PhADs. These results were discussed in terms of the possible role of GABA in thalamic systems responsible for PhAD production.

References

Nov 1, 1975·Electroencephalography and Clinical Neurophysiology·E D Bigler
Oct 1, 1976·Electroencephalography and Clinical Neurophysiology·E D Bigler
Oct 1, 1976·Pharmacology, Biochemistry, and Behavior·E D BiglerD E Shearer
Sep 1, 1976·Brain Research Bulletin·E D Bigler, E Eidelberg
Nov 1, 1966·The Journal of Physiology·W Burke, A Jervie Sefton
Nov 1, 1966·The Journal of Physiology·W Burke, A Jervie Sefton

Citations

Jan 1, 1985·The British Veterinary Journal·N G Gregory, S B Wotton
Jun 1, 1978·Pharmacology, Biochemistry, and Behavior·E D BiglerD E Fleming
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Aug 31, 2007·Annals of Nutrition & Metabolism·Cheng Gao Zhang, Sung-Jin Kim
Oct 30, 2013·ISRN Pharmacology·Priscilla Kolibea ManteElvis Ofori Ameyaw
Mar 29, 2019·Biomolecules & Therapeutics·Jung Hwa Jung, Sung-Jin Kim

Related Concepts

Bicuculline
Dose-Response Relationship, Drug
Electroencephalogram
Isoquinolines
Pentazol
Picrotoxin
Non-epileptic Convulsion
Strychnine Nitrate
Visual Cortex

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