PMID: 7541283Apr 1, 1995Paper

Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses

British Journal of Pharmacology
C E BryantT D Warner

Abstract

1. Vascular responses to acetylcholine and sodium nitroprusside in vivo and in vitro, in the isolated perfused kidney and in rings of rat thoracic aorta, were measured in rats treated chronically with NG-nitro-L-arginine methyl ester (L-NAME; approx, 70 mg kg-1) and compared to responses in age-matched control animals, and age-matched animals after the acute administration of L-NAME (3-100 mumol kg-1). Parallel experiments examined alterations in responsiveness in rings of trachea and anococcygeus muscles taken from the same animals. 2. Chronic oral administration of L-NAME elevated the blood pressure in anaesthetized animals from 114 +/- 5 mmHg to 153 +/- 11 mmHg (n = 5). The hypotensive responses to both acetylcholine (1 nmol kg-1) and sodium nitroprusside (10 nmol kg-1) were enhanced by chronic L-NAME treatment (n = 5-7) whereas acute L-NAME administration enhanced only the response to sodium nitroprusside (n = 5). 3. After chronic treatment with L-NAME, the basal perfusion pressure in the isolated perfused kidney was elevated. However, vasodilator responses to either acetylcholine (1 nmol) or sodium nitroprusside (3 nmol) were unaltered (n = 5-7). The vasodilatation induced by acetylcholine was inhibited in a concentration-...Continue Reading

References

Dec 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·V LaheraJ C Romero
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Jul 1, 1972·British Journal of Pharmacology·J S Gillespie
Mar 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K KrejcyG Raberger
Jul 1, 1993·Canadian Journal of Physiology and Pharmacology·H D AllescherM Classen

❮ Previous
Next ❯

Citations

May 15, 1998·General Pharmacology·E A Del BelF S Guimarães
Jun 26, 1998·British Journal of Pharmacology·J D McKendrickM W Radomski
Jan 6, 1999·The British Journal of Surgery·S C WeightM L Nicholson
Aug 25, 1999·The British Journal of Surgery·S C WeightM L Nicholson
Nov 1, 1995·British Journal of Pharmacology·P A KellyF M Collins
Mar 10, 2004·British Journal of Pharmacology·Alexandre A SteinerAndrej A Romanovsky
Jul 19, 2015·European Journal of Pharmacology·F Ilkay Alp YildirimB Sönmez Uydeş Doğan
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E A AfifyM S Abou Zeit-Har
May 16, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Z TodorovićS Vucković
Nov 5, 2013·The Journal of Urology·Masanori NomiyaKarl-Erik Andersson
Oct 11, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·F SekiguchiS Sunano
Feb 25, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Fumiko SekiguchiSatoru Sunano
Aug 27, 2002·Journal of Hypertension·Juan DuarteJuan Tamargo
Feb 24, 2001·Journal of Cardiovascular Pharmacology·A AleixandreA Ortega
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P JolmaI Pörsti
Dec 5, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·M WojewodaS Chlopicki
Dec 1, 2001·Clinical and Experimental Hypertension : CHE·M A BayorhM Thierry-Palmer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.