comparison of effects of different long-term iron-chelation regimens on myocardial and hepatic iron concentrations assessed with T2* magnetic resonance imaging in patients with beta-thalassemia major

International Journal of Hematology
V PerifanisMiranda Athanassiou-Metaxa

Abstract

The aim of this study was to compare the effect of different long-term chelation regimens on heart and liver iron stores with the use of T2* magnetic resonance imaging (MRI) in patients with transfusion-dependent beta-thalassemia major. Sixty-four patients (28 men, 36 women; mean age, 26.49 +/- 5.8 years) were enrolled in the study. The 3 groups were based on the chelation therapy received. The first group (19 patients) received deferiprone (DFP) (75 mg/kg per day orally), the second group (23 patients) received deferoxamine (DFO) (30-50 mg/kg per day subcutaneously at least 5 times/week), and the third group (22 patients) received a combination of DFO (30-50 mg/kg per day, 2-3 days/week) and DFP (75 mg/kg per day, 7 days/week). MRI scans were acquired with an imager equipped with a 1.5 T magnet, and the data included myocardial and hepatic iron measurements obtained by means of T2*, and ventricular volumes and ejection fractions obtained with standard cardiovascular MRI techniques. The results revealed that the DFP and the combined groups had significantly less myocardial iron than the DFO group (mean myocardial T2*, 35.77 +/- 18.3 milliseconds and 38.05 +/- 15.3 milliseconds versus 23.77 +/- 13 milliseconds [P = .02, and P = ...Continue Reading

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Citations

Jun 9, 2009·European Radiology·Paul E Sijens
Apr 1, 2010·World Journal of Gastroenterology : WJG·Konstantinos Tziomalos, Vassilios Perifanis
Jan 15, 2009·European Journal of Haematology·Athanasios ChristoforidisMiranda Athanassiou-Metaxa
Apr 28, 2017·Expert Review of Hematology·Ami Belmont, Janet L Kwiatkowski
Dec 17, 2009·Hemoglobin·Maria D CappelliniAli T Taher
Jun 20, 2020·Annals of Hematology·Shahina DaarDudley J Pennell
Jan 29, 2011·Journal of Magnetic Resonance Imaging : JMRI·Antonella MeloniAlessia Pepe
Apr 26, 2013·Therapeutic Advances in Hematology·Saumya S Jamuar, Angeline H M Lai
Aug 28, 2010·Pediatric Hematology and Oncology·Masood BazrgarMehran Karimi
May 18, 2016·Annals of the New York Academy of Sciences·Janet L Kwiatkowski
Jul 11, 2021·Clinical and Experimental Medicine·Cihangir SevimliZeynep Karakas

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