Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

Anesthesiology and Pain Medicine
Fatemeh JavaherforooshzadehMansour Soltanzadeh

Abstract

Surgery is one of the stressors that cause physiological and psychological stress. Anxiety and pain and their complications are very important in anesthesiology and many researches have been done to decrease or eliminate them. This training was done to compare the effect of melatonin and gabapentin on pain and anxiety during lumbar surgery. This study was a double-blinded clinical trial conducted on 90 patients undergoing lumbar surgery with general anesthesia in Golestan Academic Hospital in 2017. Patients were randomly assigned into 3 groups: 30 patients received 6 mg melatonin, 30 patients received 600 mg gabapentin, and 30 patients were on placebo (control), 100 minutes preoperatively. All patients were given a fixed method of anesthesia. The pain intensity and patients' satisfaction from analgesia measured at 1, 2, 6, 12, and 24 h after surgery. The anxiety was measured 15 minutes before surgery and 1, 2, 6, 12, and 24 h after surgery. In our study, there was a significant difference between mean Visual Analog Score between melatonin and gabapentin groups in comparison to placebo (P = 0.02). The intensity of anxiety among the groups was lower in melatonin and gabapentin groups in comparison to placebo (P = 0.01). The resul...Continue Reading

References

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Citations

Sep 12, 2020·Pain Practice : the Official Journal of World Institute of Pain·Zhaoqi WangJun Ma
Jul 24, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Farhad SoltaniFarahmand Kalantari
Jan 7, 2020·Anesthesiology and Pain Medicine·Washington Aspilicueta Pinto FilhoJosenilia Alves Gomes
Apr 14, 2020·Anesthesiology and Pain Medicine·Farnad Imani, Giustino Varrassi
Nov 29, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Laurens PeeneUNKNOWN European Society of Regional Anaesthesia
Dec 16, 2020·The Cochrane Database of Systematic Reviews·Bennedikte K MadsenJacob Rosenberg
Dec 2, 2021·The Journal of Pastoral Care & Counseling : JPCC·Mohammad AmiriKhadijeh Nasiriani

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Methods Mentioned

BETA
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