PMID: 6403258Feb 1, 1983Paper

Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardiac function in conscious dogs

Circulation Research
T H Hintze, S F Vatner

Abstract

The effects of nifedipine, 20 micrograms/kg, iv, and nitroglycerin, 25 micrograms/kg, iv, were compared in conscious dogs, instrumented for instantaneous and continuous measurements of coronary arterial and left ventricular (LV) diameters, arterial and LV pressures, coronary blood flow, and cardiac output. The two drugs were administered to reduce arterial pressure initially by similar amounts, by approximately 30 mm Hg. The maximal increases in large coronary arterial dimensions occurred 2-4 minutes after the initial peak reductions in arterial pressure and increases in coronary blood flow. The maximal increase in large coronary arterial cross-sectional area with nifedipine (28 +/- 2.9%) and nitroglycerin (33 +/- 5.3%) were similar. At this time, nifedipine increased coronary blood flow (114 +/- 20%) and reduced late diastolic coronary vascular resistance (-61 +/- 3.1%), whereas nitroglycerin reduced coronary blood flow (-14 +/- 1.7%) and increased late diastolic coronary vascular resistance (15 +/- 6.6%). During the time of peak large coronary arterial dilation, nifedipine reduced mean arterial pressure (-13 +/- 2.1%) and total peripheral resistance (-30 +/- 2.6%), whereas, with nitroglycerin, arterial pressure was not differ...Continue Reading

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