PMID: 10095796Mar 30, 1999

Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non-insulin-dependent diabetes mellitus patients with hypertension. Swedish Quinapril Group

Journal of Internal Medicine
J OstmanH Lithell

Abstract

To compare the long-term effects of the angiotensin-converting enzyme (ACE)-inhibitor quinapril and the cardioselective beta-adrenergic blocking agent metoprolol on glycaemic control, with glycosylated haemoglobin (HbA1c) as the principal variable, in non-insulin-dependent diabetes mellitus (NIDDM) patients with hypertension. A randomized, double-blind, double-dummy, multicentre study during 6 months preceded by a 4 week wash-out and a 3 week run-in placebo period. Quinapril (20 mg) and metoprolol (100 mg, conventional tablets) were given once daily. No change was made in the treatment of diabetes (diet and hypoglycaemic agents). Seventy-two patients fulfilling the criteria were randomized and entered the double-blind period. Twelve patients did not complete the study. Sixty patients, 26 on quinapril and 34 on metoprolol, were available for the final analysis. The effect was assessed by changes in HbA1c, the fasting serum glucose and the post-load serum glucose, C-peptide and insulin levels during the oral glucose tolerance test. In the quinapril group, the fasting serum glucose, oral glucose tolerance and the C-peptide and insulin responses, determined as the incremental area under the curves (AUC), showed no change, but the m...Continue Reading

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Citations

Jul 20, 2007·Fundamental & Clinical Pharmacology·Anna Kearney-SchwartzFaiez Zannad
Jan 28, 2010·The American Journal of Cardiology·Jeffrey S Borer, Jean-Claude Tardif
Sep 25, 2018·The Cochrane Database of Systematic Reviews·Clement LoSophia Zoungas
Sep 3, 2010·The British Journal of Nutrition·Catherine E HugginsCaryl A Nowson

Related Concepts

Quinapril hydrochloride
Adrenergic beta-Antagonists
Albuminuria
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Blood Glucose
Diastolic Blood Pressure
C-Peptide
Diabetes Mellitus, Non-Insulin-Dependent
Double-Blind Method

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