Comparison of Efficacy and Safety of Intravenous Labetalol Versus Hydralazine for Management of Severe Hypertension in Pregnancy

Journal of Obstetrics and Gynaecology of India
Purvi PatelPalak Vaishnav

Abstract

There is no consensus about the better intravenous drug between Hydralazine and Labetalol to control hypertension in cases of severe hypertension in pregnancy. Both drugs have their own advantages and disadvantages. This is a prospective randomized controlled trial comparing the efficacy and safety of intravenous Labetalol versus Hydralazine for management of severe hypertension in pregnancy. A total of 152 eligible subjects were randomised in two groups consisting 76 subjects each by envelope method. Both the groups were comparable with respect to systolic, diastolic and mean arterial blood pressure at admission. One group received Labetalol and the other Hydralazine. The number of drug doses, the time taken to achieve target blood pressure and side-effects were noted. With a single dose, Labetalol (81.5%) was able to achieve target blood pressure in a significantly higher number of cases as compared to Hydralazine (69.5%). Labetalol could help in achieving the target blood pressure faster than Hydralazine. The incidence of maternal adverse effects was comparable between the groups. Fetal outcome was comparable in both groups. Hydralazine and Labetalol both were found to be equally efficacious in reducing blood pressure in cas...Continue Reading

References

Jan 22, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·L A Magee
Oct 25, 2003·BMJ : British Medical Journal·Laura A MageePeter von Dadelszen
May 7, 2011·British Journal of Clinical Pharmacology·Laura A MageeUNKNOWN CHIPS Study Group
Aug 1, 2013·The Cochrane Database of Systematic Reviews·Lelia DuleyLeanne Jones
Jan 1, 2014·Pregnancy Hypertension·Samuel Delgado De PasqualeKerima De La Ossa
Feb 26, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Kathryn J SharmaPaola Aghajanian

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