Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease

Annals of Medicine and Surgery
Syeda Arzinda FatimaAijaz Zeeshan Khan

Abstract

The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Various treatment options were being tried all over the world. Some studies showed beneficial effects of corticosteroids in covid 19. Hence, we designed this study to compare the effect of two steroids in moderate to severe covid 19 disease. To compare the efficacy and safety of dexamethasone and methylprednisolone in moderate to severe covid 19 disease. Fatima Memorial Hospital, Lahore and Ganga Ram hospital, Lahore. Quasi experimental, interventional study. From 1st June 2020 to 30th June 2020. Sample size and technique: there were total 100 patients; 35 patients received dexamethasone and 65 were kept in methylprednisolone receiving group. The mean age of patients was 57.91 years in dexamethasone group and 54.86 years in methylprednisolone group. In dexamethasone group, there were 15 (42.8%) critically ill patients who were shifted to Intensive care unit (ICU) and seven (20%) of them needed ventilatory support, whereas in methylprednisolone group 22 (33.8%) had to be admitted in ICU with eight (12.3%) patient ...Continue Reading

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Citations

Apr 18, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Subhrojyoti BhowmickSumit Dang
Apr 4, 2021·ChemMedChem·Marcus J C Long, Yimon Aye
Jun 10, 2021·International Journal of Clinical Practice·Mónica Climente-MartíUNKNOWN Doctor Peset COVID-19 Working Group
Jul 9, 2021·The Journal of Rheumatology·Claudia D L Marques, UNKNOWN ReumaCoV Brasil Study Group
Jul 31, 2021·World Journal of Gastroenterology : WJG·Paulina Delgado-GonzalezElsa N Garza-Treviño
Jul 31, 2021·Infectious Diseases and Therapy·Matteo BassettiUNKNOWN Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP)
Sep 7, 2021·Frontiers in Pharmacology·Hsing-Yu HsuShiow-Ju Lee

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT04603729

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