Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroshi WatanabeYoshifusa Aizawa

Abstract

Suppression of implantable defibrillator discharges associated with ventricular tachyarrhythmia (VTA) has been reported for sotalol. This study aimed to investigate the efficacy of intravenous nifekalant hydrochloride in predicting the effects of oral sotalol. The present study included 14 patients who had sustained VTA associated with structural heart disease. All patients also had inducible VTA. To compare the effects of nifekalant and sotalol, programmed electrical stimulation was performed, in the basal state, after nifekalant administration, and after sotalol administration. Nifekalant and sotalol similarly prolonged the corrected QT interval and ventricular effective refractory periods, but the heart rate was slowed by sotalol only. In 4 of 5 patients whose VTA became non-inducible by nifekalant, subsequent treatment with sotalol also suppressed the inducible VTA. In all of the 9 patients non-responding to nifekalant, VTA remained inducible during sotalol treatment. Nifekalant accurately predicted the response to sotalol during electrophysiologic study in 13 of 14 patients. Of 11 patients who remained on sotalol, VTA recurred in 3 non-responders during a follow-up of 46 +/- 11 months. Nifekalant and sotalol had similar ef...Continue Reading

References

Oct 15, 1992·The American Journal of Cardiology·W JungB Lüderitz
Aug 12, 1993·The American Journal of Cardiology·P Dorian, D Newman
Jul 1, 1997·Cardiovascular Research·I KodamaJ Toyama
Dec 31, 1997·The New England Journal of Medicine·UNKNOWN Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators
Oct 22, 1998·The American Journal of Cardiology·A PacificoP D Henry
Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·P Della Bella
Apr 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi AibaShiro Kamakura
Nov 7, 2003·The New England Journal of Medicine·John P DiMarco
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Grzegorz RaczakGrazyna Swiatecka
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Masaki IgarashiNobuya Koyama
Apr 14, 2005·Pacing and Clinical Electrophysiology : PACE·Hiroshi WatanabeYoshifusa Aizawa
Apr 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Mari AminoItsuo Kodama
May 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Sergio RichterStefan H Hohnloser

❮ Previous
Next ❯

Citations

Oct 22, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken Nagao
Jul 21, 2011·World Journal of Cardiology·Ioannis N PantazopoulosTheodoros T Xanthos
Oct 30, 2015·Expert Opinion on Pharmacotherapy·J William SchleiferWin-Kuang Shen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.