Comparison of electrospun and solvent cast polylactic acid (PLA)/poly(vinyl alcohol) (PVA) inserts as potential ocular drug delivery vehicles

Materials Science & Engineering. C, Materials for Biological Applications
Rajan Sharma BhattaraiSai H S Boddu

Abstract

The purpose of this work was to develop, characterize and compare electrospun nanofiber inserts (ENIs) and solvent cast polymeric inserts (SCIs) for ocular drug delivery. ENI and SCI of 1%, 5% and 10% w/w dexamethasone were fabricated using a blend of poly-lactic acid (PLA) and poly-vinyl alcohol (PVA). Inserts were characterized for morphology, thickness, pH, drug content, drug crystallinity, in vitro drug release, sterility, dimethylformamide (DMF) and chloroform content, and cytotoxicity. The thickness of 1%, 5%, and 10% dexamethasone-loaded ENIs were found to be 50μm, 62.5μm, and 93.3μm, respectively, with good folding endurance. SCIs were brittle, with thickness values >200μm. Drug release rates from 1%, 5% and 10% ENIs were found to be 0.62μg/h, 1.46μg/h, and 2.30μg/h, respectively, while those from SCIs were erratic. DMF content in ENIs and SCIs were 0.007% w/w and 0.123% w/w, respectively, while chloroform was not detected. No cytotoxicity was observed from ENIs in cultured bovine corneal endothelial cells for up to 24h. We conclude that ENIs are better than SCIs and could be utilized as a potential delivery system for treating anterior segment ocular diseases.

Citations

Sep 3, 2017·British Journal of Pharmacology·Sahar AwwadAlastair Lockwood
Aug 23, 2019·Biomaterials Science·Young Ju SonHyuk Sang Yoo
Mar 21, 2020·Pharmaceutics·Maria Aurora GrimaudoCarmen Alvarez-Lorenzo
Apr 1, 2020·Environmental Science and Pollution Research International·Tatiana AndreaniCarlos M Pereira
Apr 10, 2021·Journal of Biomedical Materials Research. Part a·Neelima AnupRakesh K Tekade
Jun 14, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ridhdhi S DaveHeather Sheardown
Aug 16, 2021·International Journal of Pharmaceutics·Marianne J NaguibWessam H Abd-Elsalam

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