Comparison of Endoscopic Dysplasia Detection Techniques in Patients With Ulcerative Colitis: A Systematic Review and Network Meta-analysis

Inflammatory Bowel Diseases
Talat BessissowSiddharth Singh

Abstract

We assessed the comparative efficacy of different dysplasia detection techniques in patients with ulcerative colitis (UC) through a network meta-analysis and rated the quality of evidence using GRADE approach. Through a systematic literature review of multiple databases through June 30, 2017, we identified parallel-group randomized controlled trials (RCTs) in adults with long-standing UC undergoing surveillance colonoscopy with standard definition-white light endoscopy (SD-WLE), high-definition WLE (HD-WLE), narrow band imaging (NBI), or dye-based chromoendoscopy. The primary outcome was the total number of dysplastic lesions. Pairwise and network meta-analysis was performed; ranking was assessed using surface under the cumulative ranking (SUCRA) probabilities. Based on 8 parallel-group RCTs (924 patients), low-quality evidence supports chromoendoscopy over SD-WLE (odds ratio [OR], 2.37; 95% credible interval [CrI], 0.81-6.94) for any dysplasia detection, whereas very low-quality evidence supports using HD-WLE or NBI over SD-WLE (HD-WLE [vs SD-WLE]: OR, 1.21; 95% CrI, 0.30-4.85; NBI: OR, 1.68; 95% CrI, 0.54-5.22). Very low-quality evidence from indirect comparative analysis supports the use of chromoendoscopy over HD-WLE (OR, 1...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 28, 2004·Statistics in Medicine·G Lu, A E Ades
Sep 12, 2006·Alimentary Pharmacology & Therapeutics·A ObradorL Barranco
Apr 12, 2007·Zeitschrift für Gastroenterologie·B KaltzW Schmiegel
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jeroen P JansenJoseph C Cappelleri
May 23, 2012·The American Journal of Gastroenterology·Ana IgnjatovicBrian P Saunders
Dec 26, 2012·Expert Review of Gastroenterology & Hepatology·Talat Bessissow, Raf Bisschops
Jul 17, 2013·Annals of Internal Medicine·Andrea CiprianiGeorgia Salanti
Sep 26, 2014·BMJ : British Medical Journal·Milo A PuhanUNKNOWN GRADE Working Group
Apr 1, 2015·The American Journal of Gastroenterology·Chang-Ho Ryan ChoiAilsa L Hart
Dec 6, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mathurin FumerySiddharth Singh

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Citations

Mar 7, 2019·The American Journal of Gastroenterology·David T RubinMillie D Long
Jun 17, 2020·Expert Review of Gastroenterology & Hepatology·Alessandra ZilliSilvio Danese
Jul 17, 2020·Scandinavian Journal of Gastroenterology·Essi K KarjalainenAnna H Lepistö
Aug 20, 2020·Expert Review of Anticancer Therapy·Alessandro VitelloMarcello Maida
Feb 23, 2019·Inflammatory Bowel Diseases·James E EastBrian G Feagan
Sep 11, 2019·Alimentary Pharmacology & Therapeutics·Andrea IannoneGiovanni F M Strippoli
Mar 7, 2020·Frontline Gastroenterology·Christine VerdonTalat Bessissow
Oct 27, 2018·Gastrointestinal Endoscopy·Bo ShenUNKNOWN Global Interventional Inflammatory Bowel Disease Group
Apr 23, 2021·Journal of Gastroenterology·Hiroshi NakaseKazuhiko Koike
Nov 11, 2021·Gastroenterology·Shailja C Shah, Steven H Itzkowitz

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