Comparison of endoscopic submucosal dissection and surgery for superficial esophageal squamous cell carcinoma: a propensity score-matched analysis

Gastrointestinal Endoscopy
Yang Won MinYoung Mog Shim

Abstract

Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). However, long-term outcomes of ESD and esophagectomy for SESCC have not been compared. We compared the clinical outcomes of ESD and esophagectomy in a matched cohort. Patients who underwent ESD and esophagectomy for SESCC were included. We selected SESCCs without obvious submucosal invasion from the surgical database by reviewing endoscopic images. To minimize the effect of selection bias, propensity score matching was performed. Overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), and metachronous RFS were compared between the 2 groups. Adverse event rates were also compared. In a matched cohort of 120 pairs, OS, DSS, and RFS were comparable between the 2 groups. The 5-year OS, DSS, and RFS rates were 93.9% versus 91.2%, 100% versus 97.4%, and 92.8% versus 95.3% for the ESD and esophagectomy groups, respectively. The metachronous RFS was worse in the ESD group than in the esophagectomy group (P = .004). The 5-year metachronous RFS rates were 90.3% versus 100% for the ESD and esophagectomy groups, respectively. The esophagectomy group showed a higher overall adve...Continue Reading

Citations

Feb 20, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ryu IshiharaUNKNOWN Japan Gastroenterological Endoscopy Society Guidelines Committee of ESD/EMR for Esophageal Cancer
Apr 8, 2020·Clinical Endoscopy·Chan Hyuk ParkHoon Jai Chun
May 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chan Hyuk ParkHoon Jai Chun
Aug 15, 2020·The Korean Journal of Thoracic and Cardiovascular Surgery·Ga Hee Kim, Hwoon-Yong Jung
Sep 22, 2020·Clinical and Translational Gastroenterology·Yasuaki NagamiYasuhiro Fujiwara
Mar 28, 2020·United European Gastroenterology Journal
Feb 9, 2021·Clinics and Research in Hepatology and Gastroenterology·Wenjia WangYongbing Chen
Oct 28, 2020·Journal of Korean Medical Science·Ji Young ChoiHwoon Yong Jung
Oct 14, 2020·Intestinal research·Chan Hyuk ParkHoon Jai Chun
Jul 29, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Li-Xiang MeiMing-Wu Chen
Dec 28, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Cheol Min Shin

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