PMID: 2112393Apr 1, 1990Paper

Comparison of endotoxins and cutaneous burn toxin as immunosuppressants

Burns : Journal of the International Society for Burn Injuries
B G SparkesA J Brock

Abstract

Endotoxins of E. coli, S. typhosa and Ps. aeruginosa were injected i.p. into mice a few days before administration of the antigen sheep erythrocytes (SE). Antibody-forming cells (AFC) to SE were later enumerated in relation to dose of endotoxin given. In comparison a toxic lipid protein isolated from burned skin (cutaneous burn toxin or CBT) was similarly applied and found to be more inhibitory of the immune response than any of the three endotoxins. Considering the 50 per cent inhibitory doses on a molar basis CBT was found to be 1000 fold more immunosuppressive than the most inhibitory endotoxin. As the immune suppression which follows severe thermal injury involves failure of interleukin 2 (IL2) function, as a critical index of survival, the CBT was tested for its effects on the culture of a human IL2-dependent cell line in the presence of IL2. CBT inhibited the growth of these cells, however, endotoxin had no effect on their proliferation. Thus CBT, which arises by a thermally induced polymerization of skin lipid protein, is specific to burn injury and has a direct inhibitory effect on the immune response.

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Citations

Jan 1, 1993·Vaccine·B G Sparkes
Jun 1, 1996·Burns : Journal of the International Society for Burn Injuries·G Arturson
Mar 19, 2005·Burns : Journal of the International Society for Burn Injuries·J P Garner, P S J Heppell
Apr 23, 2003·Burns : Journal of the International Society for Burn Injuries·M SpiesM Allgöwer
Mar 1, 1997·Burns : Journal of the International Society for Burn Injuries·B G Sparkes
May 1, 1997·Burns : Journal of the International Society for Burn Injuries·B G Sparkes
Apr 20, 1999·Burns : Journal of the International Society for Burn Injuries·Y W Tang
Jan 12, 2000·Burns : Journal of the International Society for Burn Injuries·M DeveciU Kisa
Mar 31, 2000·Burns : Journal of the International Society for Burn Injuries·M DeveciA Inal
Aug 30, 2008·International Journal of Biological Sciences·Bingwei SunGengsheng Shi
Feb 1, 1991·Burns : Journal of the International Society for Burn Injuries·J W Davies
Aug 1, 1992·Burns : Journal of the International Society for Burn Injuries·D ScheideggerM Allgöwer
Sep 30, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Sonja M H J Scholten-JaegersUNKNOWN Dutch Burn Repository group, Martini Hospital
Aug 1, 1992·Burns : Journal of the International Society for Burn Injuries·H FeifelK Schmidt
Jul 5, 2005·Burns : Journal of the International Society for Burn Injuries·Qiren HuangYucheng Dai
Jan 1, 1995·Burns : Journal of the International Society for Burn Injuries·M AllgöwerB G Sparkes
Nov 16, 2004·Journal of Leukocyte Biology·Julie PatenaudeJacques Bernier
Apr 8, 2003·Journal of Wound Care·A B G LansdownP O'Sullivan
May 20, 2004·Journal of the Royal Army Medical Corps·P S J Heppell

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