Comparison of enzymatic and anatomic estimates of myocardial infarct size in man

D B HackelA S Jaffe


Enzymatic estimates of myocardial infarct size based on plasma levels of MB creatine kinase (MB-CK) were compared with anatomic infarct size in 49 human hearts obtained at autopsy. The patients studied had been enrolled in the Multicenter Investigation of Limitation of Infarct Size (MILIS) study program within 18 hr of the onset of acute infarction and were treated at one of five participating hospitals. Infarct size was estimated from serial measurements of plasma MB-CK made at the core laboratory for CK analysis. Hearts obtained at autopsy were studied independently by the core pathology laboratory without knowledge of the MB-CK levels or clinical results. Data from the two laboratories were compared at the data coordinating center. Of 49 hearts, 12 were excluded either because anatomic infarct size could not be established or because the infarct occurring at the time of enrollment in the MILIS study could not be distinguished with certainty from other infarcts. Of the remaining 37 hearts, peak MB-CK level was available in 36, but samples sufficient for estimation of infarct size were available in only 25. The overall correlation coefficient (Spearman) was .87 for these 25 hearts, indicating that enzymatic estimates of infarc...Continue Reading


Nov 1, 1975·British Heart Journal·R RobertsB E Sobel
Apr 1, 1978·American Heart Journal·R Roberts, B E Sobel
Sep 1, 1979·British Heart Journal·S YusufP Sleight
May 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C L Carter, L R Amundsen
Nov 19, 1976·Science·R RobertsC W Parker
Jul 1, 1975·Circulation·C R Roe, C F Starmer
Nov 1, 1975·Circulation·R RobertsB E Sobel
Feb 8, 1969·Lancet·R M NorrisP J Scott
Sep 5, 1974·The New England Journal of Medicine·W E Shell, B E Sobel
Oct 1, 1972·Circulation·B E SobelR D Yoder
May 1, 1983·The American Journal of Cardiology·J L SmithR Roberts
Jan 1, 1951·British Heart Journal·I LODGE-PATCH
Jan 1, 1936·Transactions of the American Clinical and Climatological Association·P D WhiteJ Salcedo-Salgar

❮ Previous
Next ❯


May 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·W T HermensA van der Laarse
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Panteghini
Apr 12, 2000·Journal of the American College of Cardiology·B E Sobel, M M LeWinter
Feb 1, 1991·Journal of the American College of Cardiology·T BehrenbeckR J Gibbons
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse
Feb 1, 1987·Journal of the American College of Cardiology·R Roberts
Oct 24, 1985·The New England Journal of Medicine·R Roberts
Aug 2, 2008·The New England Journal of Medicine·Christophe PiotMichel Ovize
Jul 1, 1992·Clinical and Experimental Pharmacology & Physiology·M MatsusakiK Arakawa
Feb 1, 1995·Journal of Cardiovascular Electrophysiology·D E HainesD E Bruns
Feb 1, 1988·British Heart Journal·C de ZwaanW T Hermens
May 1, 1992·Journal of Clinical Pathology·D A McCulloughR J Hillman
May 1, 1989·The Journal of Clinical Investigation·J J BilladelloD R Abendschein
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Masashi YamamotoIssei Komuro
Sep 24, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mehmet Emre AtabekSelim Kurtoglu
Jan 1, 1987·Intensive Care Medicine·M A Díaz CastellanosJ A Rueda Cuenca
Feb 1, 1996·The American Journal of the Medical Sciences·A K GeorgeT J Regan
Jan 1, 1993·The Annals of Thoracic Surgery·A Moritz, E Wolner
Oct 23, 2008·The American Journal of Cardiology·Herbert D AronowUNKNOWN GUSTO IIb and PURSUIT Trial Investigators
Jul 30, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Shinichi YamamotoJunzo Takeda
Mar 12, 2016·Journal of the American College of Cardiology·Gabriel C BrooksUNKNOWN PREDICTS Investigators
Apr 22, 2008·Echocardiography·Patricia Q BaumannDavid J Schneider
Oct 11, 2013·Journal of Interventional Cardiology·Nathan B DwyerTodd J Anderson
Jan 1, 1989·American Heart Journal·S R DevriesD R Abendschein
Mar 15, 1989·The American Journal of Cardiology·D R DufourJ Guerra
Nov 1, 1992·International Journal of Cardiology·R J BainR G Murray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.